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The human cytomegalovirus.
- S. Landolfo, M. Gariglio, G. Gribaudo, D. Lembo
- Medicine, Biology
- Pharmacology & therapeutics
- 1 June 2003
Human cytomegalovirus (HCMV), a betaherpesvirus, represents the major infectious cause of birth defects, as well as an important pathogen for immunocompromised individuals. The viral nucleocapsid… Expand
The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor for Human Cytomegalovirus Replication
Human interferon (IFN)-inducible IFI16 protein, an innate immune sensor of intracellular DNA, modulates various cell functions, however, its role in regulating virus growth remains unresolved. Here,… Expand
Cloned transcription factor MTF‐1 activates the mouse metallothionein I promoter.
Metallothioneins (MTs) are small cysteine‐rich proteins whose structure is conserved from fungi to man. MTs strongly bind heavy metals, notably zinc, copper and cadmium. Upon exposure of cells to… Expand
Human Beta‐papillomavirus infection and keratinocyte carcinomas
- K. Quint, R. Genders, +5 authors M. C. Feltkamp
- Biology, Medicine
- The Journal of pathology
- 1 January 2015
Although the role of oncogenic human Alpha‐papillomaviruses (HPVs) in the development of mucosal carcinomas at different body sites (eg cervix, anus, oropharynx) is fully recognized, a role for HPV… Expand
Interaction between inflammation and angiogenesis during different stages of cervical carcinogenesis.
OBJECTIVE The primary aim of this study was to investigate the role of angiogenesis and inflammatory cell response in cervical carcinogenesis. METHODS Formalin-fixed tissue specimens from 58… Expand
Interferons inhibit onset of murine cytomegalovirus immediate-early gene transcription.
Treatment of NIH 3T3 fibroblasts with interferon-alpha or interferon-gamma (IFN-alpha or IFN-gamma) significantly reduced murine cytomegalovirus (MCMV) replication. Determination of viral DNA in the… Expand
The retinoblastoma protein is an essential mediator that links the interferon-inducible 204 gene to cell-cycle regulation
We have previously demonstrated that overexpression of p204, a member of the Ifi 200 gene family, inhibits growth, delays G0/G1 progression into S phase, and impairs E2F-mediated transcriptional… Expand
Expression of an Altered Ribonucleotide Reductase Activity Associated with the Replication of Murine Cytomegalovirus in Quiescent Fibroblasts
ABSTRACT Ribonucleotide reductase (RNR) is an essential enzyme for the de novo synthesis of both cellular and viral DNA and catalyzes the conversion of ribonucleoside diphosphates into the… Expand
Cell Cycle Arrest by Human Cytomegalovirus 86-kDa IE2 Protein Resembles Premature Senescence
ABSTRACT Primary human embryo lung fibroblasts and adult diploid fibroblasts infected by the human cytomegalovirus (HCMV) display β-galactosidase (β-Gal) activity at neutral pH (senescence-associated… Expand
High beta-HPV DNA loads and strong seroreactivity are present in epidermodysplasia verruciformis.
- V. Dell'Oste, B. Azzimonti, +11 authors M. Gariglio
- Biology, Medicine
- The Journal of investigative dermatology
- 1 April 2009
Epidermodysplasia verruciformis (EV) is a rare disease, characterized by cutaneous warts and associated with a strong predisposition to beta-genus human papillomavirus (HPV). Earlier studies reported… Expand