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IDX184

National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Guanosine Monophosphate
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Overcoming stability challenges in the quantification of tissue nucleotides: determination of 2'-C-methylguanosine triphosphate concentration in mouse liver.
A conventional, rapid and high throughput method for tissue extraction and accurate and selective LC-MS/MS quantification of 2'-C… 
2015
2015
Pharmacokinetics of IDX184, a liver-targeted oral prodrug of 2′-methylguanosine-5′-monophosphate, in the monkey and formulation optimization for human exposure
IDX184 is a phosphoramidate prodrug of 2′-methylguanosine-5′-monophosphate, developed to treat patients infected with hepatitis C… 
2012
2012
Calamitous HCV trial casts shadow over nucleoside drugs
1015 The BMS-986094 molecule, an inhibitor of the HCV RNA polymerase nonstructural protein 5B (NS5B), is an aryl-phosphoramidate… 
2012
2012
Deals center on self-reported patient data services
2011
2011
1237 NO RESISTANCE TO IDX184 WAS DETECTED IN 3-DAY AND 14-DAY CLINICAL STUDIES OF IDX184 IN GENOTYPE 1-INFECTED HCV SUBJECTS
2011
2011
CULTURE LONG-TERM TREATMENT WITH IMINOSUGARS-BASED HCV ASSEMBLY INHIBITORS DOES NOT LEAD TO VIRAL BREAKTHROUGH IN TISSUE CULTURE
2011
2011
THE HEPATITIS C TREATMENT PIPELINE REPORT
BMS-650032 • BOCEPREVIR • CTS-1027 • DANOPREVIR • GS 9256 GS 9451 • IDX 320 • MK-5172 • TELAPREVIR • TMC435350 • VANIPREVIR VX… 
Highly Cited
2010
Highly Cited
2010
Safety and Pharmacokinetics of IDX184, a Liver-Targeted Nucleotide Polymerase Inhibitor of Hepatitis C Virus, in Healthy Subjects
ABSTRACT IDX184 is a nucleotide prodrug designed to enhance formation in the liver of the active triphosphate of 2… 
2009
2009
966 IDX184, A LIVER-TARGETED NUCLEOTIDE HCV POLYMERASE INHIBITOR: RESULTS OF A FIRST-IN-MAN SAFETY AND PHARMACOKINETIC STUDY
2008
2008
588 IN VITRO ANTIVIRAL ACTIVITY AND PHARMACOLOGY OF IDX184, A NOVEL AND POTENT INHIBITOR OF HCV REPLICATION
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