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Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents
TLDR
Human coronaviruses can persist on inanimate surfaces like metal, glass or plastic for up to 9 days, but can be efficiently inactivated by surface disinfection procedures with 62–71% ethanol, 0.5% hydrogen peroxide or 0.1% sodium hypochlorite within 1 minute. Expand
Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras.
TLDR
A series of further chimeric genomes allowing production of infectious genotype (GT) 1a, 1b, 2a, and 3a particles are created, suggesting that determinants within the structural proteins govern kinetic and efficiency of virus assembly and release and an E1-specific antiserum capable of neutralizing infectivity of all HCV chimeras is described. Expand
Hepatitis C Virus p7 Protein Is Crucial for Assembly and Release of Infectious Virions
TLDR
It is found that p7 is essential for efficient assembly and release of infectious virions across divergent virus strains, and p7 variants from different isolates deviate substantially in their capacity to promote virus production, suggesting that p 7 is an important virulence factor that may modulate fitness and in turn virus persistence and pathogenesis. Expand
Characterization of the Early Steps of Hepatitis C Virus Infection by Using Luciferase Reporter Viruses
TLDR
The data show that the mode of virus entry is conserved between these isolates and involves CD81 as a key receptor for pH-dependent virus entry and that interactions of HCV with cell surface-resident glycosaminoglycans aid in efficient infection of Huh7 cells and that CD81 acts during a postattachment step. Expand
Hepatitis C Virus Hypervariable Region 1 Modulates Receptor Interactions, Conceals the CD81 Binding Site, and Protects Conserved Neutralizing Epitopes
TLDR
It is shown that HVR1 is dispensable for RNA replication and that this domain is particularly important for infectivity of low-density particles, and functions likely optimize virus replication, facilitate immune escape, and thus foster establishment and maintenance of a chronic infection. Expand
NMR Structure and Ion Channel Activity of the p7 Protein from Hepatitis C Virus*
TLDR
The results provide the first detailed experimental structural framework for a better understanding of p7 processing, oligomerization, and ion channel gating mechanism. Expand
Anti‐infective properties of epigallocatechin‐3‐gallate (EGCG), a component of green tea
TLDR
This review summarizes the current knowledge and future perspectives on the antibacterial, antifungal and antiviral effects of the green tea constituent EGCG. Expand
Structural and Functional Characterization of Nonstructural Protein 2 for Its Role in Hepatitis C Virus Assembly*
TLDR
It is demonstrated that mutations in NS2 blocking HCV assembly can be rescued by trans-complementation, and several residues that are critical for virion formation are identified. Expand
Cyclosporine A inhibits hepatitis C virus nonstructural protein 2 through cyclophilin A
TLDR
CsA is the first anti‐HCV drug shown to act through NS2, and inhibits replication of full‐length HCV Japanese Fulminant Hepatitis genomes about 10‐fold more efficiently than subgenomic replicons. Expand
Clinical course of infection and viral tissue tropism of hepatitis C virus–like nonprimate hepaciviruses in horses
TLDR
Similar to HCV infections in humans, this work demonstrates acute and chronic stages of NPHV infection in horses with viral RNA detectable predominantly within the liver. Expand
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