ICRF 193

Known as: ICRF-193 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2015
051019912015

Papers overview

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2006
2006
Topoisomerase II is essential for cell proliferation and survival and has been a target of various anticancer drugs. ICRF-193 has… (More)
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2005
2005
DNA topoisomerase II (topo II) is involved in unlinking replicating DNA and organizing mitotic chromosomes. Topo II is the target… (More)
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2004
2004
Topoisomerase II is an essential enzyme that is targeted by a number of clinically valuable anticancer drugs. One class referred… (More)
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2003
2003
The bis-dioxopiperazine ICRF-193 has long time been considered as a pure topoisomerase II catalytic inhibitor able to exert its… (More)
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Highly Cited
2003
Highly Cited
2003
A number of clinically useful anticancer drugs, including etoposide (VP-16), target DNA topoisomerase (topo) II. These drugs… (More)
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2001
2001
Antineoplastic bis(dioxopiperazine)s, such as meso-2,3-bis(2,6-dioxopiperazin-4-yl)butane (ICRF-193), are widely believed to be… (More)
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1995
1995
Bisdioxopiperazines such as ICRF-159 and ICRF-193 have been shown to inhibit DNA topoisomerase II. To determine the molecular… (More)
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1994
1994
ICRF-193, a novel noncleavable, complex-stabilizing type topoisomerase (topo) II inhibitor, has been shown to target topo II in… (More)
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Highly Cited
1994
Highly Cited
1994
The mechanism of inhibition of eukaryotic DNA topoisomerase II [DNA topoisomerase (ATP-hydrolyzing), EC 5.99.1.3] by a member of… (More)
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1992
1992
The effect of ICRF-193, a noncleavable-complex-forming topoisomerase II inhibitor, on simian virus 40 (SV40) DNA and SV40… (More)
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