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ICRF 193

Known as: ICRF-193 
National Institutes of Health

Papers overview

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2019
2019
Casein kinase II–dependent phosphorylation of DNA topoisomerase II suppresses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast
DNA topoisomerase II (topo II) regulates the topological state of DNA and is necessary for DNA replication, transcription, and… 
2008
2008
A Three-Dimensional Quantitative Structure-Activity Analysis of a New Class of Bisphenol Topoisomerase IIα Inhibitors
After the identification of a new lead bisphenol compound that had good topoisomerase IIα (EC 5.99.1.3) inhibitory activity, a… 
2007
2007
Role of DNA topoisomerase IIbeta in neurite outgrowth.
Failure to establish neuromuscular junctions is a major phenotype of top2beta knockout mice. However, the precise mechanism for… 
2006
2006
A Three-Dimensional Quantitative Structure-Activity Relationship Study of the Inhibition of the ATPase Activity and the Strand Passing Catalytic Activity of Topoisomerase IIα by Substituted Purine…
Based on the topoisomerase IIα catalytic inhibitory activity of a previous hit compound, NSC35866, we screened 40 substituted… 
2002
2002
ATPase Domain of Eukaryotic DNA Topoisomerase II
We have prepared full-lengthDrosophila and human topoisomerase II and truncation constructs containing the amino-terminal ATPase… 
2001
2001
Decreased topoisomerase IIalpha expression confers increased resistance to ICRF-193 as well as VP-16 in mouse embryonic stem cells.
To elucidate the relationship between topoisomerase (topo) II expression and sensitivity to anti-topo II drugs in mammalian cells… 
2000
2000
Characterization of the biological and biochemical activities of F 11782 and the bisdioxopiperazines, ICRF-187 and ICRF-193, two types of topoisomerase II catalytic inhibitors with distinctive…
F 11782 is a newly identified catalytic inhibitor of topoisomerases I and II, without any detectable interaction with DNA. This… 
1997
1997
Effects of ICRF-193, a catalytic inhibitor of DNA topoisomerase II, on sister chromatid exchange
To investigate whether mammalian DNA topoisomerase II is directly involved in recombination events, the effects of ICRF-193, a… 
1996
1996
Inhibition of topoisomerase II by ICRF-193 prevents efficient replication of herpes simplex virus type 1
Cellular topoisomerase II is specifically inactivated by the drug ICRF-193. This compound turns topoisomerase II into a closed… 
1995
1995
Synthesis of simian virus 40 C-family catenated dimers in vivo in the presence of ICRF-193.
The effect of ICRF-193, a non-cleavable, complex-stabilizing type of topoisomerase II inhibitor, on SV40 DNA replication in vivo… 
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