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ICRF 193

Known as: ICRF-193 
 
National Institutes of Health

Papers overview

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2012
2012
New chromosome condensation checkpoints are identified. S-phase and topoisomerase inhibitors delay chromosome condensation. These… Expand
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Highly Cited
2003
Highly Cited
2003
A number of clinically useful anticancer drugs, including etoposide (VP-16), target DNA topoisomerase (topo) II. These drugs… Expand
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2003
2003
The bis-dioxopiperazine ICRF-193 has long time been considered as a pure topoisomerase II catalytic inhibitor able to exert its… Expand
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Highly Cited
2001
Highly Cited
2001
Antineoplastic bis(dioxopiperazine)s, such as meso-2,3-bis(2,6-dioxopiperazin-4-yl)butane (ICRF-193), are widely believed to be… Expand
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Highly Cited
2001
Highly Cited
2001
Chromatid catenation is actively monitored in human cells, with progression from G2 to mitosis being inhibited when chromatids… Expand
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2000
2000
DNA topoisomerase II uses a complex, sequential mechanism of ATP hydrolysis to catalyze the transport of one DNA duplex through a… Expand
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1995
1995
Bisdioxopiperazines such as ICRF-159 and ICRF-193 have been shown to inhibit DNA topoisomerase II. To determine the molecular… Expand
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Highly Cited
1994
Highly Cited
1994
ICRF-193, a novel noncleavable, complex-stabilizing type topoisomerase (topo) II inhibitor, has been shown to target topo II in… Expand
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Highly Cited
1994
Highly Cited
1994
The mechanism of inhibition of eukaryotic DNA topoisomerase II [DNA topoisomerase (ATP-hydrolyzing), EC 5.99.1.3] by a member of… Expand
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Highly Cited
1991
Highly Cited
1991
Several recently developed derivatives of bis(2,6-dioxopiperazine) have been shown to be new antitumor agents and are currently… Expand
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