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ICRF-159

Known as: ICI 59118, ICRF 159, ICRF159 
 
National Institutes of Health

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2008
2008
Profound modification of the structure and arrangement of the blood vessels has been shown in tumours after treatment with ICRF… Expand
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1998
1998
Anticancer drugs targeted to the nuclear enzyme DNA topoisomerase II are classified as poisons that lead to DNA breaks or… Expand
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Review
1998
Review
1998
Catalytic inhibitors of mammalian DNA topoisomerase II have been found recently in natural and synthetic compounds. These… Expand
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1998
1998
To investigate the biochemical properties of individual domains of eukaryotic topoisomerase (topo) II, two truncation mutants of… Expand
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1995
1995
A series of twelve structurally related bisdioxopiperazines that included ICRF-187 (dexrazoxane), ICRF-159 (razoxane), ICRF-193… Expand
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1995
1995
Bisdioxopiperazines such as ICRF-159 and ICRF-193 have been shown to inhibit DNA topoisomerase II. To determine the molecular… Expand
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1994
1994
Certain bis(2,6-dioxopiperazine) derivatives, which include ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl]propane; ADR-529) and… Expand
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Highly Cited
1991
Highly Cited
1991
Several recently developed derivatives of bis(2,6-dioxopiperazine) have been shown to be new antitumor agents and are currently… Expand
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Review
1982
Review
1982
Publisher Summary This chapter discusses the biological properties of ICRF-159 and related bis(dioxopiperazine) compounds. A… Expand
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1969
1969
THE aim of cancer chemotherapy to destroy the last malignant cell may be unnecessarily ambitious if inhibition of metastases… Expand
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