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ICRF-159

Known as: ICI 59118, ICRF 159, ICRF159 
 
National Institutes of Health

Papers overview

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Review
1998
Review
1998
Catalytic inhibitors of mammalian DNA topoisomerase II have been found recently in natural and synthetic compounds. These… Expand
Highly Cited
1998
Highly Cited
1998
Anticancer drugs targeted to the nuclear enzyme DNA topoisomerase II are classified as poisons that lead to DNA breaks or… Expand
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Highly Cited
1995
Highly Cited
1995
A series of twelve structurally related bisdioxopiperazines that included ICRF-187 (dexrazoxane), ICRF-159 (razoxane), ICRF-193… Expand
Highly Cited
1995
Highly Cited
1995
Bisdioxopiperazines such as ICRF-159 and ICRF-193 have been shown to inhibit DNA topoisomerase II. To determine the molecular… Expand
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Highly Cited
1994
Highly Cited
1994
Certain bis(2,6-dioxopiperazine) derivatives, which include ICRF-187 [(+)-1,2-bis(3,5-dioxopiperazinyl-1-yl]propane; ADR-529) and… Expand
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Highly Cited
1991
Highly Cited
1991
Several recently developed derivatives of bis(2,6-dioxopiperazine) have been shown to be new antitumor agents and are currently… Expand
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Review
1982
Review
1982
Publisher Summary This chapter discusses the biological properties of ICRF-159 and related bis(dioxopiperazine) compounds. A… Expand
Highly Cited
1980
Highly Cited
1980
This paper describes our experience with the use of razoxane (ICRF 159), a new anti‐mitotic drug, in the treatment of thirty‐six… Expand
1974
1974
ICRF 159, an antimitotic agent that increases the antitumor activity of most antineoplastic drugs, has now also been shown to… Expand
Highly Cited
1969
Highly Cited
1969
THE aim of cancer chemotherapy to destroy the last malignant cell may be unnecessarily ambitious if inhibition of metastases… Expand