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Hypoxia-Responsive Elements

DNA sequences in a gene's promoter region that mediate expression during hypoxia. Since unlike normal tissues, solid tumors frequently have regions… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
0519972017

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2 relations
Chromosomespromoter

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Hypoxia-Responsive Elements
promoter
Chromosomes

Papers overview

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Highly Cited
2010
Highly Cited
2010
Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development
Chondrocyte hypertrophy followed by cartilage matrix degradation and vascular invasion, characterized by expression of type X… (More)
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Highly Cited
2004
Highly Cited
2004
Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly…
Activation of the hypoxia-inducible factor alpha-subunits, HIF-1alpha and HIF-2alpha, seems to be subject to similar regulatory… (More)
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Highly Cited
2003
Highly Cited
2003
Identification of hypoxia-response element in the human endothelial nitric-oxide synthase gene promoter.
The human endothelial nitric-oxide synthase gene (heNOS) is constitutively expressed in endothelial cells, and its expression is… (More)
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Highly Cited
2000
Highly Cited
2000
Development of a hypoxia-responsive vector for tumor-specific gene therapy
We are developing new gene therapy vectors whose expression is selectively activated by hypoxia, a unique feature of human solid… (More)
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Highly Cited
2000
Highly Cited
2000
Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency.
A role of the copper protein ceruloplasmin (Cp) in iron metabolism is suggested by its ferroxidase activity and by the tissue… (More)
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Highly Cited
2000
Highly Cited
2000
Expression of hypoxia-inducible factor-1alpha in the brain of rats during chronic hypoxia.
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that regulates adaptive responses to the lack of oxygen in mammalian… (More)
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Highly Cited
1999
Highly Cited
1999
Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway.
HIF-1alpha (hypoxia-inducible factor 1alpha) is a basic-helix-loop-helix PAS (Per/Arnt/Sim) transcription factor that, under… (More)
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Highly Cited
1999
Highly Cited
1999
Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation.
The tight relationship between oxygen and iron prompted us to investigate whether the expression of transferrin receptor (TfR… (More)
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Highly Cited
1999
Highly Cited
1999
Hypoxia regulates the expression of the adrenomedullin and HIF-1 genes in cultured HL-1 cardiomyocytes.
Adrenomedullin (AM) is a hypotensive protein expressed in a variety of cells and tissues. We observed previously that the… (More)
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Highly Cited
1998
Highly Cited
1998
Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene…
Hypoxia-inducible expression has been demonstrated for many groups of mammalian genes, and studies of transcriptional control… (More)
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