Hypoxia-Responsive Elements

DNA sequences in a gene's promoter region that mediate expression during hypoxia. Since unlike normal tissues, solid tumors frequently have regions… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
0519972017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Chondrocyte hypertrophy followed by cartilage matrix degradation and vascular invasion, characterized by expression of type X… (More)
  • figure 1
  • figure 3
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Activation of the hypoxia-inducible factor alpha-subunits, HIF-1alpha and HIF-2alpha, seems to be subject to similar regulatory… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
The human endothelial nitric-oxide synthase gene (heNOS) is constitutively expressed in endothelial cells, and its expression is… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
We are developing new gene therapy vectors whose expression is selectively activated by hypoxia, a unique feature of human solid… (More)
  • figure 1
  • figure 3
  • figure 2
  • figure 4
Is this relevant?
Highly Cited
2000
Highly Cited
2000
A role of the copper protein ceruloplasmin (Cp) in iron metabolism is suggested by its ferroxidase activity and by the tissue… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that regulates adaptive responses to the lack of oxygen in mammalian… (More)
  • figure 2
  • figure 1
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1999
Highly Cited
1999
HIF-1alpha (hypoxia-inducible factor 1alpha) is a basic-helix-loop-helix PAS (Per/Arnt/Sim) transcription factor that, under… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
The tight relationship between oxygen and iron prompted us to investigate whether the expression of transferrin receptor (TfR… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Adrenomedullin (AM) is a hypotensive protein expressed in a variety of cells and tissues. We observed previously that the… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Hypoxia-inducible expression has been demonstrated for many groups of mammalian genes, and studies of transcriptional control… (More)
Is this relevant?