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Hyperoxia

Known as: Hyperoxia [Disease/Finding], Hyperoxias, oxygen stress (breathing) 
An abnormal increase in the amount of oxygen in the tissues and organs.
National Institutes of Health

Related topics

Related topics

13 relations

Broader (1)

Gas Poisoning
HypoxiaIn BloodMicrobiologicalOxygen

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Disruption of Nrf2 Impairs the Resolution of Hyperoxia-Induced Acute Lung Injury and Inflammation in Mice1
Aberrant tissue repair and persistent inflammation following oxidant-mediated acute lung injury (ALI) can lead to the development… 
Review
2007
Review
2007
Oxygen, a source of life and stress
Highly Cited
2007
Highly Cited
2007
Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia.
Prematurely born infants who require oxygen therapy often develop bronchopulmonary dysplasia (BPD), a debilitating disorder… 
Highly Cited
2006
Highly Cited
2006
Hyperoxia-induced reactive oxygen species formation in pulmonary capillary endothelial cells in situ.
Lung capillary endothelial cells (ECs) are a critical target of oxygen toxicity and play a central role in the pathogenesis of… 
Highly Cited
2006
Highly Cited
2006
Hyperoxia stimulates an Nrf2-ARE transcriptional response via ROS-EGFR-PI3K-Akt/ERK MAP kinase signaling in pulmonary epithelial cells.
Nuclear factor erythroid 2-related factor (Nrf2) confers protection against cell death induced by hyperoxia and other… 
Highly Cited
2004
Highly Cited
2004
Augmented lung injury due to interaction between hyperoxia and mechanical ventilation*
Objective:Mechanical overdistension and hyperoxia can independently cause lung injury, yet little is known about their combined… 
Highly Cited
2003
Highly Cited
2003
Independent cerebral vasoconstrictive effects of hyperoxia and accompanying arterial hypocapnia at 1 ATA.
Breathing 100% O2 at 1 atmosphere absolute (ATA) is known to be associated with a decrease in cerebral blood flow (CBF). It is… 
Review
2002
Review
2002
Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance
Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during the oxidative catabolism of heme by the… 
Highly Cited
1996
Highly Cited
1996
Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia.
Heme oxygenase (HO) catalyzes the rate-limiting step in the degradation of heme to biliverdin, which is reduced by biliverdin… 
Highly Cited
1990
Highly Cited
1990
Regulation of manganese superoxide dismutase by lipopolysaccharide, interleukin-1, and tumor necrosis factor. Role in the acute inflammatory response.
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