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Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): a randomised, double-blind, parallel-group
BACKGROUND We evaluated the effect of dual, longacting inhaled bronchodilator treatment on exacerbations in patients with severe and very severe chronic obstructive pulmonary disease (COPD). Expand
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Azithromycin for prevention of exacerbations of COPD.
BACKGROUND Acute exacerbations adversely affect patients with chronic obstructive pulmonary disease (COPD). Macrolide antibiotics benefit patients with a variety of inflammatory airway diseases. Expand
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Prevention of Exacerbations of Chronic Obstructive Pulmonary Disease with Tiotropium, a Once-Daily Inhaled Anticholinergic Bronchodilator
Context Tiotropium, a new once-daily inhaled anticholinergic bronchodilator, has been shown to improve lung function in patients with chronic obstructive pulmonary disease (COPD). Previous studiesExpand
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Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease. Department of Veterans Affairs Cooperative Study Group.
BACKGROUND AND METHODS Although their clinical efficacy is unclear and they may cause serious adverse effects, systemic glucocorticoids are a standard treatment for patients hospitalized withExpand
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Pathologic changes in the peripheral airways of young cigarette smokers.
Abstract The lungs of young smokers and controls of comparable age from a population of sudden non-hospital deaths were systematically studied to determine the relation between cigarette smoking andExpand
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Simvastatin for the prevention of exacerbations in moderate-to-severe COPD.
BACKGROUND Retrospective studies have shown that statins decrease the rate and severity of exacerbations, the rate of hospitalization, and mortality in chronic obstructive pulmonary disease (COPD).Expand
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Morphologic and morphometric effects of prolonged cigarette smoking on the small airways.
We studied lungs from 25 smokers and 14 lifelong nonsmokers, all over 40 yr of age, to examine the relationship of long-term cigarette smoking to histopathologic changes in the small airways. DespiteExpand
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Association between corticosteroid use and vertebral fractures in older men with chronic obstructive pulmonary disease.
Osteoporosis is a major complication of long-term corticosteroid administration, but the magnitude of the effect in patients with chronic obstructive pulmonary disease (COPD) is not well defined. InExpand
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A Comprehensive Care Management Program to Prevent Chronic Obstructive Pulmonary Disease Hospitalizations
BACKGROUND Improving a patient's ability to self-monitor and manage changes in chronic obstructive pulmonary disease (COPD) symptoms may improve outcomes. OBJECTIVE To determine the efficacy of aExpand
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Abnormal lung elasticity in juvenile diabetes mellitus.
Static lung pressure-volume curves, lung volumes, spirometry, diffusing capacity for CO, and airway and total pulmonary resistance were determined in 11 young men with juvenile-onset diabetesExpand
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