FAQ

Hymecromone

Known as: Methylumbelliferone, 2H-1-Benzopyran-2-one, 7-hydroxy-4-methyl-, 4-Methylumbelliferone 
A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1967-2017
051019672017

Related topics

Related topics

32 relations

Narrower (24)

3-chloro-4-methylumbelliferone4-methylumbelliferyl butyrate4-methylumbelliferyl caprylate4-methylumbelliferyl glucoside
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In Bloodadministration & dosageagonistsantagonists & inhibitors
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Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
Hymecromone
agonists
chemical synthesis
standards characteristics
4-methylumbelliferyl phosphate
4-methylumbelliferyl sulfate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Antitumor effects of hyaluronic acid inhibitor 4-methylumbelliferone in an orthotopic hepatocellular carcinoma model in mice.
Liver cirrhosis is characterized by an excessive accumulation of extracellular matrix components, including hyaluronan (HA). In… (More)
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2011
2011
Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo
Background:Hyaluronan (HA) plays crucial roles in the tumourigenicity of many types of malignant tumours. 4-Methylumbelliferone… (More)
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2011
2011
Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells.
AIMS The only FDA approved medication for colorectal cancer (CRC) prevention is celecoxib. Its adverse effects underline the need… (More)
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2011
2011
Glycosaminoglycans and glucose prevent apoptosis in 4-methylumbelliferone-treated human aortic smooth muscle cells.
Smooth muscle cells (SMCs) have a pivotal role in cardiovascular diseases and are responsible for hyaluronan (HA) deposition in… (More)
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2010
2010
Antitumor activity of hyaluronic acid synthesis inhibitor 4-methylumbelliferone in prostate cancer cells.
4-Methylumbelliferone (4-MU) is a hyaluronic acid (HA) synthesis inhibitor with anticancer properties; the mechanism of its… (More)
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Highly Cited
2009
Highly Cited
2009
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.
Hyaluronan accumulation on cancer cells and their surrounding stroma predicts an unfavourable disease outcome, suggesting that… (More)
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2009
2009
Hyaluronan orchestrates transforming growth factor-beta1-dependent maintenance of myofibroblast phenotype.
The differentiation of resident fibroblasts to myofibroblasts is central to wound healing. In the context of organ fibrosis… (More)
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Highly Cited
2008
Highly Cited
2008
The "albumin effect" and drug glucuronidation: bovine serum albumin and fatty acid-free human serum albumin enhance the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not…
Bovine serum albumin (BSA) and fatty acid-free human serum albumin (HSAFAF) reduce the K(m) values for UGT2B7 substrates by… (More)
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2005
2005
A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells.
4-Methylumbelliferone (MU) inhibits the cell surface hyaluronan (HA) formation, and that such inhibition results in suppression… (More)
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2000
2000
A highly sensitive fluorescent microplate method for the determination of UDP-glucuronosyl transferase activity in tissues and placental cell lines.
The fluorescent compound 4-methylumbelliferone (4MU) can be used to detect uridine diphosphate glucuronosyl transferase activity… (More)
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