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Hymecromone

Known as: Methylumbelliferone, 2H-1-Benzopyran-2-one, 7-hydroxy-4-methyl-, 4-Methylumbelliferone 
A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY… Expand
National Institutes of Health

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Related topics

41 relations

Narrower (33)

3-chloro-4-methylumbelliferone4-methylumbelliferyl beta-D-ribopyranoside4-methylumbelliferyl butyrate4-methylumbelliferyl caprylate
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In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Broader (1)

Indicators and Reagents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production.
CD44, an adhesion molecule that binds to the extracellular matrix, primarily to hyaluronan (HA), has been implicated in cancer… Expand
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Highly Cited
2012
Highly Cited
2012
Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells.
The molecular mechanisms that operate within the organ microenvironment to support metastatic progression remain unclear. Here… Expand
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Highly Cited
2010
Highly Cited
2010
Antitumor activity of hyaluronic acid synthesis inhibitor 4-methylumbelliferone in prostate cancer cells.
4-Methylumbelliferone (4-MU) is a hyaluronic acid (HA) synthesis inhibitor with anticancer properties; the mechanism of its… Expand
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Highly Cited
2010
Highly Cited
2010
Variation in pH Optima of Hydrolytic Enzyme Activities in Tropical Rain Forest Soils
ABSTRACT Extracellular enzymes synthesized by soil microbes play a central role in the biogeochemical cycling of nutrients in the… Expand
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Highly Cited
2008
Highly Cited
2008
The “Albumin Effect” and Drug Glucuronidation: Bovine Serum Albumin and Fatty Acid-Free Human Serum Albumin Enhance the Glucuronidation of UDP-Glucuronosyltransferase (UGT) 1A9 Substrates but Not…
Bovine serum albumin (BSA) and fatty acid-free human serum albumin (HSAFAF) reduce the Km values for UGT2B7 substrates by… Expand
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Highly Cited
2004
Highly Cited
2004
Phosphatase activity in the sea
Phosphatase is a key-enzyme in the marine environment, although life in the sea is normally not P limited. Expression of… Expand
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Highly Cited
2002
Highly Cited
2002
Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9.
(R,S)-Oxazepam is a 1,4-benzodiazepine anxiolytic drug that is metabolized primarily by hepatic glucuronidation. In previous… Expand
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Highly Cited
2001
Highly Cited
2001
Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflammation.
In this study, we investigated whether luteolin monoglucuronide was converted to free aglycone during inflammation using human… Expand
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Highly Cited
2000
Highly Cited
2000
Polymorphic Gene Regulation and Interindividual Variation of UDP-glucuronosyltransferase Activity in Human Small Intestine*
UDP-glucuronosyltransferases (UGTs) convert dietary constituents, drugs, and environmental mutagens to inactive hydrophilic… Expand
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Highly Cited
1996
Highly Cited
1996
Isolation and Characterization of a Novel cDNA Encoding a Human UDP-Glucuronosyltransferase Active on C19 Steroids*
To isolate cDNA clones encoding novel UGT2B enzymes, human prostate and LNCaP cell cDNA libraries were screened using a pool of… Expand
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