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Hymecromone
Known as:
Methylumbelliferone
, 2H-1-Benzopyran-2-one, 7-hydroxy-4-methyl-
, 4-Methylumbelliferone
Â
(More)
A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY…Â
(More)
National Institutes of Health
Topic mentions per year
Topic mentions per year
1967-2017
0
5
10
1967
2017
Related topics
Related topics
32 relations
Narrower (24)
3-chloro-4-methylumbelliferone
4-methylumbelliferyl butyrate
4-methylumbelliferyl caprylate
4-methylumbelliferyl glucoside
(More)
In Blood
administration & dosage
agonists
antagonists & inhibitors
(More)
Related mentions per year
Related mentions per year
1946-2018
1940
1960
1980
2000
2020
Hymecromone
agonists
chemical synthesis
standards characteristics
4-methylumbelliferyl phosphate
4-methylumbelliferyl sulfate
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Antitumor effects of hyaluronic acid inhibitor 4-methylumbelliferone in an orthotopic hepatocellular carcinoma model in mice.
Flavia Piccioni
,
Mariana Malvicini
,
+11 authors
Guillermo D. Mazzolini
Glycobiology
2012
Liver cirrhosis is characterized by an excessive accumulation of extracellular matrix components, including hyaluronan (HA). In…Â
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2011
2011
Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo
Eiji Arai
,
Yoichiro Nishida
,
+6 authors
Naoko Ishiguro
British Journal of Cancer
2011
Background:Hyaluronan (HA) plays crucial roles in the tumourigenicity of many types of malignant tumours. 4-Methylumbelliferone…Â
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2011
2011
Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells.
Otito Frances Iwuchukwu
,
Ronald J. Tallarida
,
Swati Nagar
Life sciences
2011
AIMS The only FDA approved medication for colorectal cancer (CRC) prevention is celecoxib. Its adverse effects underline the need…Â
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2011
2011
Glycosaminoglycans and glucose prevent apoptosis in 4-methylumbelliferone-treated human aortic smooth muscle cells.
Davide Vigetti
,
Manuela Rizzi
,
+9 authors
Alberto Passi
The Journal of biological chemistry
2011
Smooth muscle cells (SMCs) have a pivotal role in cardiovascular diseases and are responsible for hyaluronan (HA) deposition in…Â
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2010
2010
Antitumor activity of hyaluronic acid synthesis inhibitor 4-methylumbelliferone in prostate cancer cells.
Vinata B. Lokeshwar
,
Luis Lopez
,
+6 authors
Norman H. Altman
Cancer research
2010
4-Methylumbelliferone (4-MU) is a hyaluronic acid (HA) synthesis inhibitor with anticancer properties; the mechanism of its…Â
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Highly Cited
2009
Highly Cited
2009
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.
Anne Kultti
,
Sanna M Pasonen-Seppänen
,
+5 authors
Markku I. Tammi
Experimental cell research
2009
Hyaluronan accumulation on cancer cells and their surrounding stroma predicts an unfavourable disease outcome, suggesting that…Â
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2009
2009
Hyaluronan orchestrates transforming growth factor-beta1-dependent maintenance of myofibroblast phenotype.
Jason Paul Webber
,
Soma Meran
,
Robert Steadman
,
Aled O Phillips
The Journal of biological chemistry
2009
The differentiation of resident fibroblasts to myofibroblasts is central to wound healing. In the context of organ fibrosis…Â
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Highly Cited
2008
Highly Cited
2008
The "albumin effect" and drug glucuronidation: bovine serum albumin and fatty acid-free human serum albumin enhance the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not…
Andrew Rowland
,
Kathleen M Knights
,
Peter Ian Mackenzie
,
John O. Miners
Drug metabolism and disposition: the biological…
2008
Bovine serum albumin (BSA) and fatty acid-free human serum albumin (HSAFAF) reduce the K(m) values for UGT2B7 substrates by…Â
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2005
2005
A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells.
Shuichi Yoshihara
,
Atsushi Kon
,
+5 authors
Keiichi Takagaki
FEBS letters
2005
4-Methylumbelliferone (MU) inhibits the cell surface hyaluronan (HA) formation, and that such inhibition results in suppression…Â
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2000
2000
A highly sensitive fluorescent microplate method for the determination of UDP-glucuronosyl transferase activity in tissues and placental cell lines.
A. C. Collier
,
Malcolm Drummond Tingle
,
Jeffrey A Keelan
,
J. Paxton
,
M Darren Mitchell
Drug metabolism and disposition: the biological…
2000
The fluorescent compound 4-methylumbelliferone (4MU) can be used to detect uridine diphosphate glucuronosyl transferase activity…Â
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