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Humanized Monoclonal Antibody 3F8
Known as:
Hu3F8
, Humanized Anti-GD2 Antibody 3F8
A humanized monoclonal antibody directed against the human tumor-associated antigen GD2, with potential antineoplastic activity. Upon vaccination…
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National Institutes of Health
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Related topics
Related topics
1 relation
antigen binding
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Humanized 3F8 Anti-GD2 Monoclonal Antibody Dosing With Granulocyte-Macrophage Colony-Stimulating Factor in Patients With Resistant Neuroblastoma: A Phase 1 Clinical Trial
B. Kushner
,
I. Cheung
,
S. Modak
,
E. Basu
,
S. Roberts
,
N. Cheung
JAMA oncology
2018
Corpus ID: 53527735
Importance Chimeric and murine anti-GD2 antibodies are active against neuroblastoma, but the development of neutralizing…
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2017
2017
Phase I trial of anti-GD2 monoclonal antibody hu3F8 plus GM-CSF: Impact of body weight, immunogenicity and anti-GD2 response on pharmacokinetics and survival
I. Cheung
,
B. Kushner
,
S. Modak
,
E. Basu
,
S. Roberts
,
N. Cheung
Oncoimmunology
2017
Corpus ID: 46813889
ABSTRACT Fifty-seven stage 4 patients with refractory/relapsed neuroblastoma were enrolled in a phase I trial (Clinicaltrials.gov…
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2015
2015
Alteration of Electrostatic Surface Potential Enhances Affinity and Tumor Killing Properties of Anti-ganglioside GD2 Monoclonal Antibody hu3F8*
Qi Zhao
,
Mahiuddin Ahmed
,
Hong-fen Guo
,
I. Cheung
,
N. Cheung
The Journal of Biological Chemistry
2015
Corpus ID: 23808317
Background: Modest affinity to carbohydrate targets limits the therapeutic efficacy of antibodies to tumor antigens, such as…
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2014
2014
Large Molecule Therapeutics Preclinical Evaluation of Multistep Targeting of Diasialoganglioside GD 2 Using an IgG-scFv Bispeci fi c Antibody with High Af fi nity for GD 2 and DOTA Metal Complex
S. Cheal
,
Hong Xu
,
Hong-fen Guo
,
P. Zanzonico
,
S. Larson
,
N. Cheung
2014
Corpus ID: 6169824
Bispecific antibodies (BsAb) haveproven to beuseful targeting vectors for pretargeted radioimmunotherapy (PRIT). We sought to…
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Highly Cited
2012
Highly Cited
2012
Humanizing murine IgG3 anti-GD2 antibody m3F8 substantially improves antibody-dependent cell-mediated cytotoxicity while retaining targeting in vivo
N. Cheung
,
Hong-fen Guo
,
Jian Hu
,
D. Tassev
,
I. Cheung
Oncoimmunology
2012
Corpus ID: 1825752
Murine IgG3 anti-GD2 antibody m3F8 has shown anti-neuroblastoma activity in Phase I/II studies, where antibody-dependent cell…
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