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Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer.
Selumetinib produces clinically meaningful increases in iodine uptake and retention in a subgroup of patients with thyroid cancer that is refractory to radioiodine; the effectiveness may be greater in patients with RAS-mutant disease.
MIRD Pamphlet No. 23: Quantitative SPECT for Patient-Specific 3-Dimensional Dosimetry in Internal Radionuclide Therapy
- Y. Dewaraja, E. Frey, M. Ljungberg
- Medicine, Environmental ScienceThe Journal of Nuclear Medicine
- 1 August 2012
An overview of 3-dimensional SPECT methods and requirements for internal dosimetry at both regional and voxel levels is presented, and Combined SPECT/CT image-based methods are emphasized, because the CT-derived anatomic information allows one to address multiple technical factors that affect SPECT quantification while facilitating the patient-specific voxels-level dosimetric calculation itself.
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation.
- D. Chakravarty, E. Santos, J. Fagin
- Biology, MedicineThe Journal of clinical investigation
- 1 December 2011
The data show that thyroid tumors carrying BRAF(V600E) mutations are exquisitely dependent on the oncoprotein for viability and that genetic or pharmacological inhibition of its expression or activity is associated with tumor regression and restoration of RAI uptake in vivo in mice.
Positron emission tomography: a review of basic principles, scanner design and performance, and current systems.
- P. Zanzonico
- MedicineSeminars in nuclear medicine
- 1 April 2004
The current article views the technical basis of the remarkable advance of this modality—the underlying princiles of PET and the basic design and performance haracteristics of PET scanners—emphasizing edicated “full-ring” devices and including multiodality (ie, PET-CT) and special-purpose devices.
Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe
- Evan Phillips, Oula Peñate-Medina, M. Bradbury
- Biology, MedicineScience Translational Medicine
- 29 October 2014
The authors found that the nanoparticles were not toxic in a small group of five patients with metastatic melanoma and that the particles were excreted intact via the kidneys and bladder, suggesting safe use of these particles in human cancer diagnostics.
Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma.
The sensitive, real-time detection and imaging of lymphatic drainage patterns, particle clearance rates, nodal metastases, and differential tumor burden in a large-animal model of melanoma highlighted the distinct potential advantage of this multimodal platform for staging metastatic disease in the clinical setting.
Reproducibility of intratumor distribution of (18)F-fluoromisonidazole in head and neck cancer.
Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in…
Routine Quality Control of Clinical Nuclear Medicine Instrumentation: A Brief Review*
- P. Zanzonico
- MedicineJournal of Nuclear Medicine
- 1 July 2008
This article reviews routine quality-control (QC) procedures for current nuclear medicine instrumentation, including the survey meter, dose calibrator, well counter, intraoperative probe, organ…
The epichaperome is an integrated chaperome network that facilitates tumour survival
It is found that under conditions of stress, such as malignant transformation fuelled by MYC, the chaperome becomes biochemically ‘rewired’ to form a network of stable, survival-facilitating, high-molecular-weight complexes.