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Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer.
BACKGROUND Metastatic thyroid cancers that are refractory to radioiodine (iodine-131) are associated with a poor prognosis. In mouse models of thyroid cancer, selective mitogen-activated proteinExpand
Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma.
Nanoparticle-based materials, such as drug delivery vehicles and diagnostic probes, currently under evaluation in oncology clinical trials are largely not tumor selective. To be clinicallyExpand
MIRD Pamphlet No. 23: Quantitative SPECT for Patient-Specific 3-Dimensional Dosimetry in Internal Radionuclide Therapy
In internal radionuclide therapy, a growing interest in voxel-level estimates of tissue-absorbed dose has been driven by the desire to report radiobiologic quantities that account for the biologicExpand
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation.
Advanced human thyroid cancers, particularly those that are refractory to treatment with radioiodine (RAI), have a high prevalence of BRAF (v-raf murine sarcoma viral oncogene homolog B1) mutations.Expand
EFFECTS OF TIME OF ADMINISTRATION AND DIETARY IODINE LEVELS ON POTASSIUM IODIDE (KI) BLOCKADE OF THYROID IRRADIATION BY 131I FROM RADIOACTIVE FALLOUT
Abstract—Radioiodines, particularly 131I, may be released into the environment in breach-of-containment nuclear reactor accidents and localize in and irradiate the thyroid with an attendant risk ofExpand
Positron emission tomography: a review of basic principles, scanner design and performance, and current systems.
  • P. Zanzonico
  • Medicine
  • Seminars in nuclear medicine
  • 1 April 2004
S N INCE THE INCEPTION of positron emission tomography (PET) several decades ago, PET canner design and performance have improved ramatically. The number of detector elements has ncreased from 20 toExpand
Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in
OBJECTIVES Vascular endothelial growth factor (VEGF), a potent angiogenic mediator, can be delivered to targeted tissues by means of a replication-deficient adenovirus (Ad) vector. We hypothesizedExpand
Routine Quality Control of Clinical Nuclear Medicine Instrumentation: A Brief Review*
This article reviews routine quality-control (QC) procedures for current nuclear medicine instrumentation, including the survey meter, dose calibrator, well counter, intraoperative probe, organExpand
MIRD Pamphlet No. 24: Guidelines for Quantitative 131I SPECT in Dosimetry Applications
The reliability of radiation dose estimates in internal radionuclide therapy is directly related to the accuracy of activity estimates obtained at each imaging time point. The recently published MIRDExpand
Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe
Ultrasmall inorganic hybrid optical-PET imaging particles were found to be safe and physiologically stable in patients with melanoma. First-in-Human Nanoparticles for Molecular Cancer ImagingExpand
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