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Homoserine O-Succinyltransferase

Known as: Succinyltransferase, Homoserine, Transsuccinylase, Homoserine, O-Succinyltransferase, Homoserine 
The first enzyme in the METHIONINE biosynthetic pathway, this enzyme catalyzes the succinylation reaction of L-homoserine to O-succinyl-L-homoserine… 
National Institutes of Health

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Related topics

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In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects

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metA protein, E coli

Papers overview

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Highly Cited
2007
Highly Cited
2007
Role of Homoserine Transacetylase as a New Target for Antifungal Agents
ABSTRACT Microbial amino acid biosynthesis is a proven yet underexploited target of antibiotics. The biosynthesis of methionine… 
2005
2005
Polyphosphate Kinase Protects Salmonella enterica from Weak Organic Acid Stress
ABSTRACT Mutants of Salmonella enterica lacking polyphosphate kinase (ppk) grow poorly in the presence of the weak organic acids… 
Highly Cited
2005
Highly Cited
2005
Effects of Deregulation of Methionine Biosynthesis on Methionine Excretion in Escherichia coli
ABSTRACT Several regulators of methionine biosynthesis have been reported in Escherichia coli, which might represent barriers to… 
Highly Cited
1999
Highly Cited
1999
Enzyme-catalyzed acylation of homoserine: mechanistic characterization of the Escherichia coli metA-encoded homoserine transsuccinylase.
The first unique step in bacterial and plant methionine biosynthesis involves the activation of the gamma-hydroxyl of homoserine… 
Highly Cited
1997
Highly Cited
1997
Three-dimensional structure of tetrahydrodipicolinate N-succinyltransferase.
The conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA is catalyzed by… 
Review
1996
Review
1996
The DAP pathway to lysine as a target for antimicrobial agents.
2.4 2.5 2.6 2.7 3 4 5 Introduction : The Diaminopimelate Pathway to LLysine Enzymes of the Diaminopimelate Pathway L… 
Highly Cited
1996
Highly Cited
1996
Three-dimensional structure of the lipoyl domain from the dihydrolipoyl succinyltransferase component of the 2-oxoglutarate dehydrogenase multienzyme complex of Escherichia coli.
A sub-gene encoding the lipoyl domain of the dihydrolipoyl succinyltransferase polypeptide chain of the 2-oxoglutarate… 
1986
1986
Studies on the active site of succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase. Characterization using analogs of tetrahydrodipicolinate.
Cyclic and acyclic analogs of tetrahydrodipicolinate (THDPA) are evaluated in a study of the active site of succinyl-CoA… 
1986
1986
Peptides of 2-aminopimelic acid: antibacterial agents that inhibit diaminopimelic acid biosynthesis.
Succinyl-CoA:tetrahydrodipicolinate-N-succinyltransferase is a key enzyme in the biosynthesis of diaminopimelic acid (DAP), a… 
1975
1975
Growth rate of Enterobacteriaceae at elevated temperatures: limitation by methionine
The effect of elevated temperatures on growth rate was studied in five strains of Enterobacteriaceae. In all the strains tested a… 
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