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Homology Modeling

An approach to modeling a protein structure based on an initial sequence alignment to a protein with a known 3D structure. After evaluating and… 
National Institutes of Health

Papers overview

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2011
2011
Toward understanding the mechanism of action of the yeast multidrug resistance transporter Pdr5p: a molecular modeling study.
Review
2010
Review
2010
Homology modeling of G-protein-coupled receptors with X-ray structures on the rise.
GPCRs are key components of signal transduction pathways and are important drug targets. Recently determined GPCR structures… 
Highly Cited
2009
Highly Cited
2009
Homology modeling of human Toll‐like receptors TLR7, 8, and 9 ligand‐binding domains
Toll‐like receptors (TLRs) play a key role in the innate immune system. The TLR7, 8, and 9 compose a family of intracellularly… 
Highly Cited
2007
Highly Cited
2007
Docking and homology modeling explain inhibition of the human vesicular glutamate transporters
As membrane transporter proteins, VGLUT1–3 mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals… 
2005
2005
Role of the conserved threonine 309 in mechanism of oxidation by cytochrome P450 2D6.
Highly Cited
2003
Highly Cited
2003
An atomic detail model for the human ATP binding cassette transporter P‐glycoprotein derived from disulphide cross‐ linking and homology modeling
The multidrug resistance P‐glycoprotein mediates the extrusion of chemotherapeutic drugs from cancer cells. Characterization of… 
Highly Cited
2003
Highly Cited
2003
First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling.
The first cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor is reported. The inhibitor was… 
Highly Cited
2000
Highly Cited
2000
A new model for 20‐hydroxyecdysone and dibenzoylhydrazine binding: A homology modeling and docking approach
The ecdysone receptor (ECR), a nuclear transcription factor controlling insect development, is a novel target for insecticides… 
Highly Cited
1999
Highly Cited
1999
The accessory subunit of mtDNA polymerase shares structural homology with aminoacyl-tRNA synthetases: implications for a dual role as a primer recognition factor and processivity clamp.
The accessory subunit of the heterodimeric mtDNA polymerase (polgamma) from Drosophila embryos is required to maintain the… 
Highly Cited
1997
Highly Cited
1997
Structure and assembly of the catalytic region of human complement protease C1r: a three-dimensional model based on chemical cross-linking and homology modeling.
C1r is the modular serine protease responsible for autocatalytic activation of C1, the first component of the complement… 
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