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C1q and tumor necrosis factor superfamily: modularity and versatility.
C1q is the target recognition protein of the classical complement pathway and a major connecting link between innate and acquired immunity. As a charge pattern recognition molecule of innateExpand
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The Crystal Structure of the Globular Head of Complement Protein C1q Provides a Basis for Its Versatile Recognition Properties*
C1q is a versatile recognition protein that binds to an amazing variety of immune and non-immune ligands and triggers activation of the classical pathway of complement. The crystal structure of theExpand
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Expression patterns of GASA genes in Arabidopsis thaliana: the GASA4 gene is up-regulated by gibberellins in meristematic regions
The GASA gene family previously identified in Arabidopsis belongs to a wide-spread class of genes found in mono- and dicotyledonous plants, all structurally related to the original GA-regulated GAST1Expand
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Substrate Specificities of Recombinant Mannan-binding Lectin-associated Serine Proteases-1 and -2*
Mannan-binding lectin (MBL)-associated serine proteases-1 and 2 (MASP-1 and MASP-2) are homologous modular proteases that each interact with MBL, an oligomeric serum lectin involved in innateExpand
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Structure and activation of the C1 complex of complement: unraveling the puzzle.
Abstract C1, the multimolecular protease that triggers the classical pathway of complement, has a major role in the host defense against pathogens. It also participates in other biological functions,Expand
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C1q Binds Phosphatidylserine and Likely Acts as a Multiligand-Bridging Molecule in Apoptotic Cell Recognition1
Efficient apoptotic cell clearance is critical for maintenance of tissue homeostasis, and to control the immune responses mediated by phagocytes. Little is known about the molecules that contributeExpand
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Structural insights into the innate immune recognition specificities of L‐ and H‐ficolins
Innate immunity relies critically upon the ability of a few pattern recognition molecules to sense molecular markers on pathogens, but little is known about these interactions at the atomic level.Expand
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Interaction of 125I‐labelled complement subcomponents C r and C s with protease inhibitors in plasma
Activation of the classical pathway of the complement system 1s brought about by the bmding of the first component of complement, Cl, to antibodyantigen complexes. Cl is a glycoprotein complex,Expand
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Studies on the interactions between C‐reactive protein and complement proteins
Several studies have investigated the interactions between C‐reactive protein (CRP) and various complement proteins but none of them took into consideration the different structural forms of CRP. TheExpand
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Residue Lys57 in the Collagen-Like Region of Human L-Ficolin and Its Counterpart Lys47 in H-Ficolin Play a Key Role in the Interaction with the Mannan-Binding Lectin-Associated Serine Proteases and
L- and H-ficolins are serum oligomeric defense proteins consisting of a collagen-like region and a fibrinogen-like recognition domain that bind to pathogen- and apoptotic cell-associated molecularExpand
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