Homology modeling of human Toll‐like receptors TLR7, 8, and 9 ligand‐binding domains
- T. Wei, J. Gong, F. Jamitzky, W. Heckl, R. Stark, Shaila C. Rössle
- BiologyProtein Science
- 1 August 2009
Three‐dimensional structures for the leucine‐rich repeat ectodomains of human TLR7, 8, and 9 are developed based on homology modeling that support previously reported essential ligand‐binding residues and provide a basis to identify three potential receptor dimerization mechanisms.
A Wheat SIMILAR TO RCD-ONE Gene Enhances Seedling Growth and Abiotic Stress Resistance by Modulating Redox Homeostasis and Maintaining Genomic Integrity[C][W]
It is shown here that the wheat SRO has PARP activity; such activity could be manipulated to improve the growth of seedlings exposed to salinity stress by modulating redox homeostasis and maintaining genomic stability.
Structural insight of a concentration-dependent mechanism by which YdiV inhibits Escherichia coli flagellum biogenesis and motility
YdiV inhibits FlhD4C2 only at relatively high concentrations, and its structure and the negative staining electron microscopy reconstruction of YdiV4–FlhD 4C2 suggested that the third and fourth Y diV molecule bound to the Flh D4C 2 complex through squeezing into the ring-like structure of Flhd4C1 between the two internal D subunits, and the complex lost DNA-binding ability.
Crystal Structure and Biochemical Features of EfeB/YcdB from Escherichia coli O157
Biochemical data show that the production of protoporphyrin IX (PPIX) is closely related to the peroxidation activity, and dramatically enhanced fluorescence excitation and emission of EfeB-PPIX was observed, implying this protein may be used as a red color fluorescence marker.
Inhibition of Toll-like receptors TLR4 and 7 signaling pathways by SIGIRR: a computational approach.
Lack of SIGIRR/TIR8 aggravates hydrocarbon oil‐induced lupus nephritis
TIR8/SIGIRR protects from hydrocarbon oil‐induced lupus by suppressing the TLR7‐mediated activation of dendritic cells, via its intracellular BB loop.
Evolution of the IL17 receptor family in chordates: a new subfamily IL17REL
Sequence and structure analyses reveal functional similarities and distinctions between the different IL17Rs, and a group of IL17RE-like proteins were identified from mammalians to lower vertebrates, indicating that IL17REL may represent a unique subfamily of IL 17Rs.
The REC domain mediated dimerization is critical for FleQ from Pseudomonas aeruginosa to function as a c-di-GMP receptor and flagella gene regulator.
TollML: a database of toll-like receptor structural motifs
TollML, a database that integrates all of the TLR sequencing data from the NCBI protein database, is described and searchable categories can be searched quickly using an easy-to-use web interface and dynamically displayed by graphics.