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Homeobox Protein DLX-5

Known as: DLX5 
Homeobox protein DLX-5 (289 aa, ~32 kDa) is encoded by the human DLX5 gene. This protein is involved in the positive regulation of osteoblast… 
National Institutes of Health

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9 relations
Cell NucleusDLX5 geneDNA-Binding ProteinsGenes, Regulator

Papers overview

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2014
2014
GATA4 negatively regulates osteoblast differentiation by downregulation of Runx2
Osteoblasts are specialized mesenchymal cells that are responsible for bone formation. In this study, we examine the role of… 
2014
2014
Transitory expression of Dlx5 and Dlx6 in maxillary arch epithelial precursors is essential for upper jaw morphogenesis
Asymmetric, articulated jaws are characteristic of most vertebrate species; they derive from the first pharyngeal arch (PA1… 
2012
2012
Expression of osteoblastic and osteoclastic genes during spontaneous regeneration and autotransplantation of goldfish scale: a new tool to study intramembranous bone regeneration.
2009
2009
Dlx5 Is a Cell Autonomous Regulator of Chondrocyte Hypertrophy in Mice and Functionally Substitutes for Dlx6 during Endochondral Ossification
The axial and appendicular skeleton of vertebrates develops by endochondral ossification, in which skeletogenic tissue is… 
2009
2009
Increased bone resorption and osteopenia in Dlx5 heterozygous mice
Distal‐less (Dlx) homeobox transcription factors play a central role in the control of osteogenesis. In particular, Dlx5… 
2008
2008
DLX5 overexpression impairs osteogenic differentiation of human bone marrow stromal cells.
2007
2007
Studies on the role of Dlx5 in regulation of chondrocyte differentiation during endochondral ossification in the developing mouse limb
The homeodomain transcription factor Dlx5 has been implicated in the regulation of chondrocyte and osteoblast differentiation… 
2003
2003
Dlx5 regulates chondrocyte differentiation at multiple stages.
Endochondral ossification, in which cartilaginous templates are progressively replaced by marrow and bone, represents the… 
2002
2002
Enhancement of osteogenesis in vitro by a novel osteoblast differentiation-promoting compound, TAK-778, partly through the expression of Msx2.
2002
2002
Transcriptional regulation restricting bone sialoprotein gene expression to both hypertrophic chondrocytes and osteoblasts
This study identifies a cis‐acting element that confers tissue‐restricted expression to the bone sialoprotein (BSP) gene. Using… 
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