• Publications
  • Influence
SOX2 Silencing in Glioblastoma Tumor‐Initiating Cells Causes Stop of Proliferation and Loss of Tumorigenicity
TLDR
Silencing SOX2 in freshly derived glioblastoma tumor‐initiating cells (TICs) indicates that these cells, despite the many mutations they have accumulated, stop proliferating and lose tumorigenicity in immunodeficient mice. Expand
Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation.
TLDR
Evidence is provided that the difference between Otx1 and Otx2 null mice phenotypes originates from their divergent expression patterns, and it is hypothesized that the differential post-transcriptional control existing between VE and epiblast cells may potentially contribute to fundamental regulatory mechanisms required for head specification. Expand
Regionalization within the mammalian telencephalon is mediated by changes in responsiveness to Sonic Hedgehog.
TLDR
Later in development, Sonic Hedgehog induces ventral neurons with patterns of gene expression characteristic of the lateral ganglionic eminence, the embryonic structure from which the striatum is derived, suggesting that temporally regulated changes in Sonic hedgehog responsiveness are integral in the sequential induction of basal telencephalic structures. Expand
p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts.
TLDR
It is demonstrated that p38 alpha and beta isoforms also control muscle-gene expression posttranscriptionally, by stabilizing critical myogenic transcripts, by establishing a biochemical link between differentiation-activated p38 signaling and turnover of myogenic mRNAs. Expand
NK Cells Recognize and Kill Human Glioblastoma Cells with Stem Cell-Like Properties1
TLDR
All stem cell-cultured glioblastoma cells analyzed did not express protective amounts of HLA class I molecules, while expressing various ligands of activating NK receptors that triggered optimal NK cell cytotoxicity. Expand
Implication of OTX2 in Pigment Epithelium Determination and Neural Retina Differentiation
TLDR
Bromodeoxyuridine labeling in combination with immunohistochemistry with anti-OTX2 antiserum and different cell-specific markers were used to determine that OTX2-positive cells are postmitotic neuroblasts undergoing differentiation into several, if not all, of the distinct cell types present in the chick retina. Expand
EMX2 protein in the developing mouse brain and olfactory area
TLDR
The graded distribution of EMX2 along antero-posterior and medial-lateral axes of the primitive cortex prefigures a role of this protein in the subdivision of the cortex in cytoarchitectonic regions and possibly functional areas, whereas its presence in Cajal-Retzius cells suggests a role in the process of cortical lamination. Expand
Comparative Analysis of DNA Repair in Stem and Nonstem Glioma Cell Cultures
TLDR
It is concluded that glioma stem cells display elongated cell cycle and enhanced basal activation of checkpoint proteins that might contribute to their radioresistance, whereas enhanced DNA repair is not a common feature of these cells. Expand
Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain
TLDR
The data indicate that an Otx dose-dependent repressive effect coordinates proper positioning of Shh and Fgf8 expression and it is proposed that this mechanism may provide both A–P and D–V positional information to neuronal precursors located within the midbrain. Expand
Emx2 Promotes Symmetric Cell Divisions and a Multipotential Fate in Precursors from the Cerebral Cortex
TLDR
It is described that retroviral transduction of the transcription factor Emx2 in precursors from the cerebral cortex results in a significant increase of large clones that are generated mostly by symmetric cell divisions and contain multiple cell types, comprising neurons and glial cells. Expand
...
1
2
3
4
5
...