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Krox-20 controls myelination in the peripheral nervous system
TLDR
It is demonstrated here that Krox-20 is also activated in Schwann cells before the onset of myelination and that its disruption blocks Schwann Cells at an early stage in their differentiation, thus preventing myelinations in the peripheral nervous system.
Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5.
TLDR
The defects observed in Dlx5-/- mutant animals suggest multiple and independent roles of this gene in the patterning of the branchial arches, in the morphogenesis of the vestibular organ and in osteoblast differentiation.
Jaw transformation with gain of symmetry after Dlx5/Dlx6 inactivation: Mirror of the past?
TLDR
This finding supports the notion that Dlx genes are homeotic genes associated with morphological novelty in the vertebrate lineage and first homeotic‐like transformation found in this Hox‐free region after gene inactivation.
The Dlx5 homeobox gene is essential for vestibular morphogenesis in the mouse embryo through a BMP4-mediated pathway.
TLDR
It is proposed that development of the semicircular canals and the vestibular inner ear requires the independent control of several homeobox genes, which appear to exert their function via tight regulation of BPM4 expression and the regional organization of cell differentiation, proliferation, and apoptosis.
Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system
TLDR
It is shown that certain formulations of plasmid DNA with linear polyethylenimine (22 kDa PEI, ExGene 500) can produce complexes that are sufficiently small and stable in physiological fluids so as to provide high diffusibility.
Multiple pituitary and ovarian defects in Krox-24 (NGFI-A, Egr-1)-targeted mice.
TLDR
The data suggest that Krox-24 may have two distinct molecular functions in the anterior pituitary: transcriptional activation of the LHbeta gene in gonadotropes and control of cell proliferation and/or survival in somatotropes by unknown mechanisms.
Polyethylenimine-based intravenous delivery of transgenes to mouse lung
TLDR
Findings indicate that the PEI/DNA complexes pass the capillary barrier in the lung, and linear PEI has promise as a vector for intravenous transfer of therapeutic genes.
Adult neural stem cell cycling in vivo requires thyroid hormone and its alpha receptor
TLDR
It is concluded that liganded‐TRα is critical for neurogenesis in the adult mammalian brain, and direct TH transcriptional effect was revealed by targeted gene transfer to stem cells in vivo.
Multiple functions of Dlx genes.
TLDR
Dlx genes comprise a highly conserved family of homeobox genes homologous to the distal-less (Dll) gene of Drosophila that seem to have multiple functions at different stages of development or in different tissues and cell types.
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