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Heterocyclic Amine Carcinogen

A cyclic compound that has at least one nitrogen incorporated into its structure instead of carbon and contains an amino (-NH2) group. Heterocyclic… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach.
SCOPE MicroRNA (miRNA) profiles are altered in chronic conditions such as cardiovascular disease, diabetes, neurological… Expand
Highly Cited
2011
Highly Cited
2011
NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP)
NADPH oxidase/dual‐oxidase (Nox/Duox) family members have been implicated in nuclear factor kappa‐B (NFκB)‐mediated inflammation… Expand
2007
2007
2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potentiates nitrosation of a heterocyclic amine carcinogen by nitric oxide.
Although nitrosation plays an important role in initiation of carcinogenesis, the reactive nitrogen oxygen species (RNOS… Expand
2002
2002
Resveratrol modulates human mammary epithelial cell O-acetyltransferase, sulfotransferase, and kinase activation of the heterocyclic amine carcinogen N-hydroxy-PhIP.
Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural antioxidant found in plants, such as grapes, that studies suggest has… Expand
2001
2001
DNA adduct levels and absence of tumors in female rapid and slow acetylator congenic hamsters administered the rat mammary carcinogen 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine
N‐acetyltransferases (EC 2.3.1.5) catalyze O‐acetylation of heterocyclic amine carcinogens to DNA‐reactive electrophiles that… Expand
2000
2000
Characterization of an ATP-dependent pathway of activation for the heterocyclic amine carcinogen N-hydroxy-2-amino-3-methylimidazo[4, 5-f]quinoline.
2-amino-3-methylimidazo[4,5-f]quinoline (IQ) is one of several mutagenic and carcinogenic heterocyclic amines formed during the… Expand
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Highly Cited
1997
Highly Cited
1997
Effects of marinating on heterocyclic amine carcinogen formation in grilled chicken.
This study compared heterocyclic aromatic amines in marinated and unmarinated chicken breast meat flame-broiled on a propane… Expand
Highly Cited
1997
Highly Cited
1997
Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human cytochrome P4501B1.
Cytochrome P4501B1 (CYP1B1) is the most recently identified member of the dioxin-inducible CYP1 family. CYP1B1 is constitutively… Expand
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Highly Cited
1994
Highly Cited
1994
Induction of mammary tumors in female Sprague-Dawley rats by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and effect of dietary fat.
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a carcinogen found in cooked meat, was determined to be a mammary… Expand
1992
1992
Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice.
The metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP), a heterocyclic amine carcinogen detected in cooked… Expand
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