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Association between glutathione S-transferase M1, P1, and T1 genetic polymorphisms and development of breast cancer.
- K. Helzlsouer, O. Selmin, +6 authors D. Bell
- Biology, Medicine
- Journal of the National Cancer Institute
- 1 April 1998
It is suggested that genetic variability in members of the GST gene family may be associated with an increased susceptibility to breast cancer. Expand
An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.
The findings suggest that the allele encoding low activity COMT may be an important contributor to the postmenopausal development of breast cancer in certain women. Expand
A nested case-control study of non-Hodgkin lymphoma and serum organochlorine residues
There was a strong dose-response relation between quartiles of total lipid-corrected serum PCB concentrations and risk of non-Hodgkin lymphoma overall and there was also evidence suggesting that seropositivity for the Epstein-Barr virus early antigen potentiated the effects of serum PCBs. Expand
Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochrome P450 1B1.
- J. Kim, K. Stansbury, N. Walker, M. Trush, P. Strickland, T. Sutter
- Chemistry, Medicine
- 1 October 1998
The results of these studies indicate that cytochrome P450 1B1 carries out metabolism of B[a]P along the pathway to the postulated ultimate carcinogen, the diol epoxide 2, at rates much higher than P 450 1A2 but less than P4501A1. Expand
Serum concentrations of organochlorine compounds and the subsequent development of breast cancer.
- K. Helzlsouer, A. Alberg, +9 authors G. Comstock
- Cancer epidemiology, biomarkers & prevention : a…
- 1 June 1999
Exposure to relatively high concentrations of DDE or PCBs showed no evidence of contributing to an increased risk of breast cancer up to 20 years later, and these associations remained consistent regardless of lactation history and length of the follow-up interval. Expand
XRCC1 genetic polymorphism and breast cancer risk.
Department of Industrial Hygiene and Toxicology,Finnish Institute of Occupational Health, Helsinki, FinlandCorrespondence to Daehee Kang, MD, PhD, Department of Preventive Medicine,Seoul National… Expand
Dietary Benzo[a]Pyrene Intake and Risk of Colorectal Adenoma
- R. Sinha, M. Kulldorff, M. Gunter, P. Strickland, N. Rothman
- Cancer Epidemiology Biomarkers & Prevention
- 1 August 2005
Evidence is provided that dietary BaP plays a role in colorectal adenoma etiology and is more strongly associated with BaP intake estimated from all foods. Expand
Relationship between the Val158Met polymorphism of catechol O-methyl transferase and breast cancer.
A case-control study to assess the potential influence of catechol O-methyl transferase (COMT) genotype on the risk of breast cancer in Korean women found that women with at least one COMT lower enzyme activity associated allele ( COMT-L) were at elevated risk for breast cancer. Expand
Polychlorinated biphenyl levels in peripheral blood and non-Hodgkin's lymphoma: a report from three cohorts.
The results from these three cohorts suggest that concentrations of certain PCBs in blood are associated with increased risk of NHL and lipid-corrected plasma or serum concentrations. Expand
Oxidation of xenobiotics by recombinant human cytochrome P450 1B1.
- T. Shimada, E. Gillam, T. Sutter, P. Strickland, F. Guengerich, H. Yamazaki
- Biology, Medicine
- Drug metabolism and disposition: the biological…
- 1 May 1997
CYP1B1 has catalytic activities overlapping CYP1A1 and CYP 1A2 with respect to the oxidation of drugs and model P450 substrates, although the relative catalytic roles in these three P450 enzymes differ depending upon the substrates examined. Expand