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Hereditary Breast and Ovarian Cancer Syndrome

Known as: HBOC Syndrome, Syndromes, HBOC, Hereditary Breast and Ovarian Cancer 
An autosomal dominant inherited syndrome caused by mutations in the BRCA1 or BRCA2 genes. Patients are at high risk of developing breast cancer… 
National Institutes of Health

Related topics

Related topics

13 relations
BRCA1 ProteinBRCA1 geneBRCA1 protein, humanBRCA2 Protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Management of hereditary breast and ovarian cancer
Hereditary breast and ovarian cancer (HBOC) syndrome represents 5−10% of all breast cancers. In Japan, the HBOC syndrome is… 
Highly Cited
2015
Highly Cited
2015
Hereditary breast and ovarian cancer syndrome
Souhrn Jedinci se syndromem hereditárního karcinomu prsu a ovarií, tedy nosičky mutací v genech BRCA1 a BRCA2, mají vyšší riziko… 
Review
2013
Review
2013
Hereditary breast and ovarian cancer susceptibility genes (review).
Women with hereditary breast and ovarian cancer (HBOC) syndrome represent a unique group who are diagnosed at a younger age and… 
Highly Cited
2012
Highly Cited
2012
Clinical significance of large rearrangements in BRCA1 and BRCA2
Current estimates of the contribution of large rearrangement (LR) mutations in the BRCA1 (breast cancer 1, early onset) and BRCA2… 
Highly Cited
2009
Highly Cited
2009
Hereditary breast and ovarian cancer syndrome : the impact of race on uptake of genetic counseling and testing.
Breast cancer is a significant cause of morbidity and mortality in the United States. Although breast cancer is more common among… 
Highly Cited
2003
Highly Cited
2003
Communication with close and distant relatives in the context of genetic testing for hereditary breast and ovarian cancer in cancer patients
The psychological aspects of genetic testing for hereditary breast and ovarian cancer (HBOC) in cancer patients (diagnostic… 
Highly Cited
1999
Highly Cited
1999
Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas
Although the link between the BRCA1 tumour–suppressor gene and hereditary breast and ovarian cancer is established, the role, if… 
Highly Cited
1996
Highly Cited
1996
Identification of a RING protein that can interact in vivo with the BRCA1 gene product
The hereditary breast and ovarian cancer gene, BRCA1, encodes a large polypeptide that contains the cysteine–rich RING motif, a… 
Highly Cited
1995
Highly Cited
1995
Rapid detection of BRCA1 mutations by the protein truncation test
More than 75% of the reported mutations in the hereditary breast and ovarian cancer gene, BRCA1, result in truncated proteins. We… 
Highly Cited
1992
Highly Cited
1992
Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancers.
BACKGROUND Mutations of the tumor suppressor gene p53 have been identified in breast cancer cell lines, and some breast… 
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