Hereditary Breast and Ovarian Cancer Syndrome

Known as: HBOC Syndrome, Syndromes, HBOC, Hereditary Breast and Ovarian Cancer 
An autosomal dominant inherited syndrome caused by mutations in the BRCA1 or BRCA2 genes. Patients are at high risk of developing breast cancer… (More)
National Institutes of Health

Papers overview

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2015
2015
Approximately, 7 % of all breast cancers (BC) and 11-15 % of ovarian cancers (OC) are associated with inherited predisposition… (More)
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Highly Cited
2014
Highly Cited
2014
To optimize the molecular diagnosis of hereditary breast and ovarian cancer (HBOC), we developed a next-generation sequencing… (More)
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2011
2011
About 5-10% of breast and ovarian carcinomas are hereditary and most of these result from germline mutations in the BRCA1 and… (More)
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2009
2009
Hereditary breast and ovarian cancer syndrome is an inherited cancer-susceptibility syndrome. The hallmarks of this syndrome are… (More)
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Review
2009
Review
2009
Hereditary breast and ovarian cancer syndrome is an inherited cancer-susceptibility syndrome characterized by multiple family… (More)
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Highly Cited
2003
Highly Cited
2003
This study addresses the prevalence of ATM mutations and the association with breast cancer in Austrian families selected for a… (More)
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Highly Cited
2003
Highly Cited
2003
The psychological aspects of genetic testing for hereditary breast and ovarian cancer (HBOC) in cancer patients (diagnostic… (More)
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Highly Cited
2000
Highly Cited
2000
Although BRCA1/2 testing has increasingly entered clinical practice, much is to be learned about the most effective ways to… (More)
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1996
1996
Nine different germ-line mutations in the BRCA1 breast and ovarian cancer susceptibility gene were identified in 15 of 47… (More)
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Highly Cited
1992
Highly Cited
1992
BACKGROUND Mutations of the tumor suppressor gene p53 have been identified in breast cancer cell lines, and some breast… (More)
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