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Chronic infection with hepatitis C virus (HCV) affects 170 million people worldwide and is the leading cause of cirrhosis in… Expand BACKGROUND/AIMS
End-stage liver disease accounts for one in forty deaths worldwide. Chronic infections with hepatitis B virus… Expand Hepatitis C virus (HCV) infection causes chronic liver diseases and is a global public health problem. Detailed analyses of HCV… Expand Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research… Expand MicroRNAs are small RNA molecules that regulate messenger RNA (mRNA) expression. MicroRNA 122 (miR-122) is specifically expressed… Expand Antiviral immunity against a pathogen is mounted upon recognition by the host of virally associated structures. One of these… Expand BACKGROUND
A sustained virological response (SVR) rate of 41% has been achieved with interferon alfa-2b plus ribavirin therapy of… Expand An estimated 170 million persons worldwide are infected with hepatitis C virus (HCV), a major cause of chronic liver disease… Expand BACKGROUND
Only 15 to 20 percent of patients with chronic hepatitis C have a sustained virologic response to interferon therapy… Expand The nucleotide sequence of the RNA genome of the human hepatitis C virus (HCV) has been determined from overlapping cDNA clones… Expand