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Hepatic Stellate Cells

Known as: Cells, Hepatic Stellate, Stellate Cells, Hepatic, Cell, Hepatic Stellate 
A star-shaped cell in the liver associated with the development of fibrosis. When stellate cells are activated in response to an injury, they… 
National Institutes of Health

Related topics

Related topics

9 relations
Connective and Soft TissueHepatic macrophageHepatic perisinusoidal spaceMicrobiological

Broader (1)

Hepatocyte

Narrower (1)

Ito Cells

Papers overview

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Highly Cited
2018
Highly Cited
2018
Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α
Rationale: Hepatic stellate cells (HSCs) are liver-specific pericytes regulating vascular remodeling during hepatic fibrosis… 
Highly Cited
2008
Highly Cited
2008
Fucoidan partly prevents CCl4-induced liver fibrosis
Highly Cited
2007
Highly Cited
2007
Prevention of liver cirrhosis in rats by curcumin
Background and Aim: Curcumin, the major polyphenolic compound in turmeric, has been shown to attenuate hepatic damage in several… 
Highly Cited
2006
Highly Cited
2006
Oxidative‐stress and IL‐6 mediate the fibrogenic effects of rodent Kupffer cells on stellate cells
The impact of Kupffer cells (KCs) on the hepatic stellate cell (HSC) fibrogenic response was examined in an in vitro coculture… 
Highly Cited
2002
Highly Cited
2002
Cytochrome P450 2E1-derived Reactive Oxygen Species Mediate Paracrine Stimulation of Collagen I Protein Synthesis by Hepatic Stellate Cells*
To evaluate possible fibrogenic effects of CYP2E1-dependent generation of reactive oxygen species, a model was developed using co… 
Highly Cited
2001
Highly Cited
2001
N-Acetylcysteine Induces Cell Cycle Arrest in Hepatic Stellate Cells through Its Reducing Activity*
Activation of hepatic stellate cells (HSC) has been identified as a critical step in hepatic fibrogenesis and is regulated by… 
Review
2001
Review
2001
Transcriptional Regulation in Hepatic Stellate Cells
Modulation of gene expression through altered transcription regulates stellate cell behavior in normal liver and following… 
Highly Cited
2001
Highly Cited
2001
Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells
Hepatic stellate cells (HSC) are the main producers of type I collagen in fibrotic liver, and transforming growth factor‐β (TGF… 
Highly Cited
1999
Highly Cited
1999
A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture
Hepatic stellate cells are the major cellular sources of extracellular matrix in chronic liver diseases leading to fibrosis. We… 
Highly Cited
1998
Highly Cited
1998
Transformation‐dependent susceptibility of rat hepatic stellate cells to apoptosis induced by soluble fas ligand
Cytokine‐driven activation of hepatic stellate cells (HSC) in tissue injury and inflammation is a key pathogenetic event in liver… 
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