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Hepatic Stellate Cells

Known as: Cells, Hepatic Stellate, Stellate Cells, Hepatic, Cell, Hepatic Stellate 
A star-shaped cell in the liver associated with the development of fibrosis. When stellate cells are activated in response to an injury, they… 
National Institutes of Health

Related topics

Related topics

9 relations
Connective and Soft TissueHepatic macrophageHepatic perisinusoidal spaceMicrobiological

Broader (1)

Hepatocyte

Narrower (1)

Ito Cells

Papers overview

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Highly Cited
2011
Highly Cited
2011
Septum transversum‐derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver
The septum transversum mesenchyme (STM) signals to induce hepatogenesis from the foregut endoderm. Hepatic stellate cells (HSCs… 
Highly Cited
2008
Highly Cited
2008
Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis.
Activation of hepatic stellate cells (HSC), a key event in liver fibrosis, is caused by diminished adipogenic transcription. This… 
Review
2005
Review
2005
The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis
Liver fibrosis and its end-stage disease cirrhosis are major world health problems arising from chronic injury of the liver by a… 
Highly Cited
2003
Highly Cited
2003
Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors.
BACKGROUND & AIMS In liver fibrosis, alterations within the space of Disse microenvironment occur and facilitate further… 
Highly Cited
2003
Highly Cited
2003
The Role of Focal Adhesion Kinase-Phosphatidylinositol 3-Kinase-Akt Signaling in Hepatic Stellate Cell Proliferation and Type I Collagen Expression*
Following a fibrogenic stimulus, the hepatic stellate cell (HSC) undergoes a complex activation process associated with increased… 
Highly Cited
2002
Highly Cited
2002
Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro.
BACKGROUND & AIMS The ligand-dependent transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) is… 
Highly Cited
2002
Highly Cited
2002
Inhibition of Apoptosis of Activated Hepatic Stellate Cells by Tissue Inhibitor of Metalloproteinase-1 Is Mediated via Effects on Matrix Metalloproteinase Inhibition
The activated hepatic stellate cell (HSC) is central to liver fibrosis as the major source of collagens I and III and the tissue… 
Highly Cited
2000
Highly Cited
2000
Peroxisome Proliferator-activated Receptors and Hepatic Stellate Cell Activation*
The present study examined the roles of peroxisome proliferator-activated receptors (PPAR) in activation of hepatic stellate… 
Highly Cited
2000
Highly Cited
2000
Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells.
BACKGROUND & AIMS Proliferation and migration of hepatic stellate cells (HSCs) and expression of chemokines are involved in the… 
Highly Cited
1998
Highly Cited
1998
Fibrogenic effect of oxidative stress on rat hepatic stellate cells
Oxidative stress is associated with liver fibrosis and with hepatic stellate cell (HSC) activation in vivo. However, it remains… 
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