Hemophilia B

Known as: Deficiency, plasma thromboplastin component, Deficiency, functional factor IX, Deficiency, PTC 
A deficiency of blood coagulation factor IX inherited as an X-linked disorder. (Also known as Christmas Disease, after the first patient studied in… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
BACKGROUND In patients with severe hemophilia B, gene therapy that is mediated by a novel self-complementary adeno-associated… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Prophylactic factor replacement in patients with hemophilia B improves outcomes but requires frequent injections. A… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Hemophilia B, an X-linked disorder, is ideally suited for gene therapy. We investigated the use of a new gene therapy… (More)
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Highly Cited
2007
Highly Cited
2007
A longstanding goal for the treatment of hemophilia B is the development of a gene transfer strategy that can maintain sustained… (More)
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Highly Cited
2005
Highly Cited
2005
Adeno-associated virus 8 (AAV8), a new member of the AAV family isolated from nonhuman primates, is an attractive candidate for… (More)
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Highly Cited
2003
Highly Cited
2003
Hemophilia B is an X-linked coagulopathy caused by absence of functional coagulation factor IX (F.IX). Previously, we established… (More)
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Highly Cited
2002
Highly Cited
2002
Hemophilia B is an X-linked coagulopathy caused by absence of functional coagulation factor IX (FIX). Using adeno-associated… (More)
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Highly Cited
1999
Highly Cited
1999
Hemophilia B is a severe X-linked bleeding diathesis caused by the absence of functional blood coagulation factor IX, and is an… (More)
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Highly Cited
1999
Highly Cited
1999
Hemophilia B, or factor IX deficiency, is an X-linked recessive disorder occurring in about 1 in 25,000 males. Affected… (More)
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Highly Cited
1999
Highly Cited
1999
Mice generated by disrupting the clotting factor IX gene exhibit severe bleeding disorder and closely resemble the phenotype seen… (More)
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