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Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor
Summary.  von Willebrand disease (VWD) is a bleeding disorder caused by inherited defects in the concentration, structure, or function of von Willebrand factor (VWF). VWD is classified into threeExpand
The mutational spectrum of type 1 von Willebrand disease: Results from a Canadian cohort study.
In order to evaluate the changes within the VWF gene that might contribute to the pathogenesis of type 1 von Willebrand disease (VWD), a large multicenter Canadian study was undertaken. We presentExpand
Founder von Willebrand factor haplotype associated with type 1 von Willebrand disease.
To date, no dominant mutation has been identified in a significant proportion of patients with type 1 von Willebrand disease (VWD). In this study, we examined 70 families as part of the Canadian TypeExpand
ISTH/SSC bleeding assessment tool: a standardized questionnaire and a proposal for a new bleeding score for inherited bleeding disorders
F . RODEGHIERO,* A . TOSETTO,* T . ABSH IRE , D . M . A R NO L D , B . COLLE R ,§ P . J AMES ,– C. NEUNER T** and D . L I LL ICRAP ON BEHALF OF THE I STH/SSC JOINT VWF AND PER INATAL/ PED IA TR I CExpand
Tailored prophylaxis in severe hemophilia A: interim results from the first 5 years of the Canadian Hemophilia Primary Prophylaxis Study
Summary.  Background: Prophylactic treatment for severe hemophilia A is likely to be more effective than treatment when bleeding occurs, however, prophylaxis is costly. We studied an inception cohortExpand
Generation and validation of the Condensed MCMDM‐1VWD Bleeding Questionnaire for von Willebrand disease
Summary.  Background: Given the challenges involved in obtaining accurate bleeding histories, attempts at standardization have occurred and the value of quantifying hemorrhagic symptoms has beenExpand
The Factor VIII acute phase response requires the participation of NFkappaB and C/EBP.
Coagulation Factor VIII is an acute phase protein in humans that has recently been shown to be transcriptionally responsive to interleukin-6. In this study, we have demonstrated that the human FactorExpand
Factor VIII gene inversions in severe hemophilia A: results of an international consortium study.
Twenty-two molecular diagnostic laboratories from 14 countries participated in a consortium study to estimate the impact of Factor VIII gene inversions in severe hemophilia A. A total of 2,093Expand
Disseminated intravascular coagulation in patients with 2019‐nCoV pneumonia
  • D. Lillicrap
  • Medicine
  • Journal of thrombosis and haemostasis : JTH
  • 24 March 2020
In late December 2019, a new infectious disease emerged in the city of Wuhan in Hubei Province, China. A novel betacoronavirus, 2019nCoV, capable of human-to-human transmission, has been identifiedExpand
Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance.
Thrombocytopenia has been consistently reported following the administration of adenoviral gene transfer vectors. The mechanism underlying this phenomenon is currently unknown. In this study, we haveExpand
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