D. Lillicrap

Publications487
h-index62
Citations13,477
Highly Influential Citations373
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Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor
TLDR
Six categories of von Willebrand disease correlate with important clinical features and therapeutic requirements, and certain VWD types, especially type 1 and type 2A, encompass several pathophysiologic mechanisms that sometimes can be distinguished by appropriate laboratory studies.
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Founder von Willebrand factor haplotype associated with type 1 von Willebrand disease.
TLDR
It is demonstrated that all the families with the Tyr1584Cys mutation share a common, evolved VWF haplotype, suggesting that this mutation is ancient.
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ISTH/SSC bleeding assessment tool: a standardized questionnaire and a proposal for a new bleeding score for inherited bleeding disorders
TLDR
This research presents a novel and scalable approach that combines cell therapy and Hematology with oncology to provide real-time information about the immune status of the central nervous system of children aged six to 18 months.
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The mutational spectrum of type 1 von Willebrand disease: Results from a Canadian cohort study.
TLDR
It was somewhat more likely to identify putative mutations in cases with lower VWF levels, and the contribution of other factors, such as ABO blood group, seems more important in milder cases.
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Generation and validation of the Condensed MCMDM‐1VWD Bleeding Questionnaire for von Willebrand disease
TLDR
The Condensed MCMDM‐1VWD Bleeding Questionnaire is an efficient, effective tool in the evaluation of patients for VWD.
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Tailored prophylaxis in severe hemophilia A: interim results from the first 5 years of the Canadian Hemophilia Primary Prophylaxis Study
TLDR
Most boys with severe hemophilia A will probably have little bleeding and good joint function with tailored prophylaxis, while infusing less FVIII than usually required for traditional prophYLaxis.
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Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance.
TLDR
It is concluded that VWF and P-selectin are critically involved in a complex platelet-leukocyte-endothelial interplay, resulting in platelet activation and accelerated platelet clearance following adenovirus administration.
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Life in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A.
TLDR
The half-life of VWF appears to be the limiting factor that has confounded attempts to extend the half- life of rFVIII, and a greater understanding of the interaction between FVIII and VWF is required to drive novel bioengineering strategies for products that either prolong the survival ofVWF or limit VWF-mediated clearance of FV III.
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Disseminated intravascular coagulation in patients with 2019‐nCoV pneumonia
  • D. Lillicrap
  • Medicine
    Journal of thrombosis and haemostasis : JTH
  • 24 March 2020
TLDR
Findings highlight that evidence of DIC is a strong predictor of mortality in patients developing pneumonia with 2019-nCoV, and a cytokine storm effect may be developing in these individuals with severe disease.
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Theories of Blood Coagulation
TLDR
The goal of this article is to review the evolution of the theories of coagulation and their proposed models to serve as a tool when reviewing the research and practice literature that was published in the context of these different theories over time.
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