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Heavy Chain Disease

Known as: BALLARD DISEASE, HCD, Heavy Chain Disease [Disease/Finding] 
A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the… 
National Institutes of Health

Related topics

Related topics

30 relations
Atypical lymphocyteB lymphoblastB-LymphocytesDIH1 gene

Narrower (4)

Immunoproliferative Small Intestinal DiseaseRIV immunoglobulin variant protein, humanWis heavy-chain disease protein, humanmu-Chain Disease

Broader (1)

gammopathy

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Gamma heavy chain disease lacks the MYD88 L265p mutation associated with lymphoplasmacytic lymphoma
Gamma heavy chain disease (gHCD) is defined by an abnormally truncated IgG heavy chain monoclonal protein that lacks associated… 
Highly Cited
2013
Highly Cited
2013
A large synthetic peptide and phosphopeptide reference library for mass spectrometry–based proteomics
We present a peptide library and data resource of >100,000 synthetic, unmodified peptides and their phosphorylated counterparts… 
Highly Cited
2013
Highly Cited
2013
Unambiguous Phosphosite Localization using Electron-Transfer/Higher-Energy Collision Dissociation (EThcD)
We recently introduced a novel scheme combining electron-transfer and higher-energy collision dissociation (termed EThcD), for… 
Highly Cited
2011
Highly Cited
2011
Combining high-energy C-trap dissociation and electron transfer dissociation for protein O-GlcNAc modification site assignment.
Mass spectrometry-based studies of proteins that are post-translationally modified by O-linked β-N-acetylglucosamine (O-GlcNAc… 
Review
2010
Review
2010
Striding Out With Parkinson Disease: Evidence-Based Physical Therapy for Gait Disorders
Although Parkinson disease (PD) is common throughout the world, the evidence for physical therapy interventions that enable long… 
Highly Cited
2009
Highly Cited
2009
Quantitative mitochondrial phosphoproteomics using iTRAQ on an LTQ-Orbitrap with high energy collision dissociation.
With the use of iTRAQ labeling and mass spectrometry on an LTQ-Orbitrap with HCD capability, we assessed relative changes in… 
Highly Cited
2004
Highly Cited
2004
Cerebral Microvascular Responses to Hypercholesterolemia: Roles of NADPH Oxidase and P-Selectin
Abstract— Although hypercholesterolemia is widely accepted as a major risk factor for coronary artery and peripheral vascular… 
Highly Cited
1998
Highly Cited
1998
Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease.
Human naive and germinal center (GC) B cells were sorted by flow cytometry and rearranged VH region genes were amplified and… 
Highly Cited
1969
Highly Cited
1969
Partial Deletion in the Heavy Chain Disease Protein ZUC
HEAVY chain disease1,2 is characterized by the presence in serum and urine of a protein associated structurally with the Fc… 
Highly Cited
1964
Highly Cited
1964
Heavy chain disease—A new disorder of serum γ-globulins: Report of the first case
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