• Publications
  • Influence
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.
BACKGROUND Acute myeloid leukemia (AML) is a heterogeneous disease with respect to presentation and clinical outcome. The prognostic value of recently identified somatic mutations has not beenExpand
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CTCF Mediates Interchromosomal Colocalization Between Igf2/H19 and Wsb1/Nf1
Gene transcription may be regulated by remote enhancer or insulator regions through chromosome looping. Using a modification of chromosome conformation capture (3C) and fluorescence in situExpand
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Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern
Pretreatment cytogenetics is a known predictor of outcome in hematologic malignancies. However, its usefulness in adult acute lymphoblastic leukemia (ALL) is generally limited to the presence of theExpand
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Human Endothelial Cell Life Extension by Telomerase Expression*
Normal human endothelial cells, like other somatic cells in culture, divide a limited number of times before entering a nondividing state called replicative senescence. Expression of the catalyticExpand
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Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells
  • N. Sun, N. Panetta, +8 authors J. Wu
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 15 September 2009
Ectopic expression of transcription factors can reprogram somatic cells to a pluripotent state. However, most of the studies used skin fibroblasts as the starting population for reprogramming, whichExpand
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HER2 Expression in Gastric and Gastroesophageal Junction Adenocarcinoma in a US Population: Clinicopathologic Analysis With Proposed Approach to HER2 Assessment
Recent evidence suggests that trastuzumab, a monoclonal antibody which targets HER2, in combination with chemotherapy is a therapeutic option in patients with HER2-positive gastric orExpand
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Terminal deletion of 6p results in a recognizable phenotype
With improved cytogenetic techniques, small deletions and duplications are being identified with increased frequency. We report four cases with terminal deletions involving the 6p24‐ and 6p25‐pterExpand
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Loss of SMARCB1/INI1 expression in poorly differentiated chordomas
Chordomas are malignant neoplasms that typically arise in the axial spine and primarily affect adults. When chordomas arise in pediatric patients they are more likely to display unusual histologicalExpand
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Expression Profiles of MYC Protein and MYC Gene Rearrangement in Lymphomas
MYC translocations are a defining feature of Burkitt lymphoma and a group of diffuse large B-cell lymphoma (DLBCL) with inferior outcome. However, the clinical relevance of MYC gene rearrangement andExpand
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Long-term remission of Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic hematopoietic cell transplantation from matched sibling donors: a 20-year experience with the
Allogeneic hematopoietic cell transplantation (HCT) is the only known curative modality for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL). Sixty-sevenExpand
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