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Halofenate

Known as: Benzeneacetic acid, 4-chloro-alpha-(3-(trifluoromethyl)phenoxy)-, 2-(acetylamino)ethyl ester, Halofenate [Chemical/Ingredient] 
A selective peroxisome proliferator-activated receptor gamma (PPAR-gamma) modulator with antilipidemic activity. Halofenate also decreases fasting… 
National Institutes of Health

Related topics

Related topics

11 relations

Broader (2)

Hypolipidemic AgentsUricosuric Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (1)

MK-185

Papers overview

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1977
1977
Comparison of clofibrate with halofenate in diabetics with hyperlipidaemia.
In a double-blind, randomized study which lasted 48 weeks the effects of clofibrate and halofenate were compared in maturity… 
1977
1977
The Effect of Halofenate – Free Acid on Aggregation – the Release Reaction, Coagulant Activity, and Lipid Metabolism of Human Platelets
Summary Halofenate – free acid (HFA), the major metabolite of the hypolipidemic drug, halofenate, inhibited platelet aggregation… 
1976
1976
Halofenate and clofibrate: mechanism of hypotriglyceridemic action in the rat.
Rats fed a fat-free diet containing no drug, 0.02% or 0.10% halofenate, or 0.25% clofibrate for 14 days were injected… 
1976
1976
The Effect of Halofenate or Halofenate Free Acid on Human, Rat and Guinea Pig Platelet Aggregation
Summary Halofenate free acid (HFA), the major metabolite of the hypolipemic agent halofenate, blocked the secondary phase of… 
1976
1976
A two‐year crossover therapeutic trial with halofenate and clofibrate
Twelve patients with Type IV hyperlipoproteinemia were treated with clofibrate and halofenate in a double blind, crossover trial… 
1976
1976
Changes in serum thyrotropin (TSH) in man during halofenate administration.
Halofenate, a serum lipid-lowering agent which inhibits binding of thyroid hormone to thyroxine-binding globulin (TBG), was… 
1976
1976
The distribution of halofenate in plasma: a comparative analysis using Scatchard vs. stepwise association constants.
The distribution of Halofenate between the free and albumin bound forms was calculated by the use of two computer programs using… 
Highly Cited
1975
Highly Cited
1975
Drugs affecting the synthesis of glycerides and phospholipids in rat liver. The effects of clofibrate, halofenate, fenfluramine, amphetamine, cinchocaine, chlorpromazine, demethylimipramine…
The effects on glycerolipid synthesis of a series of compounds including many drugs were investigated in cell-free preparations… 
1972
1972
Effect of halofenate on binding of various drugs to human plasma proteins and on the plasma half-life of antipyrine in monkeys.
Halofenate free acid was shown to reduce markedly the binding of salicylic acid and aspirin in human plasma. Similar, but much… 
1972
1972
Effects of a new hypolipidemic agents, MK-185, on serum thyroxine-binding globulin (TBG) and dialyzable fraction thyroxine.
MK-185 (halofenate) is a hypo-lipidemic agent which has been shown in short-term clinical trials in hyperlipidemic patients to…