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HSV-Tk Gene

Known as: HSV-Tk, Herpes Simplex Virus Thymidine Kinase Gene 
Herpes simplex virus thymidine kinase (HSV-Tk) gene encodes thymidine kinase protein, which is important for herpes simplex virus infection. The TK… 
National Institutes of Health

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Related topics

3 relations
PhosphorylationSimplexvirusVirus Physiological Phenomena

Papers overview

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Highly Cited
1996
Highly Cited
1996
Gene therapy for α‐fetoprotein‐producing human hepatoma cells by adenovirus‐mediated transfer of the herpes simplex virus thymidine kinase gene
We have developed a recombinant replication‐defective adenovirus containing human α‐fetoprotein (AFP) promoter/enhancer to direct… 
Highly Cited
1995
Highly Cited
1995
Adenovirus-mediated gene therapy for human head and neck squamous cell cancer in a nude mouse model.
Adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene followed by ganciclovir administration was used to… 
Highly Cited
1989
Highly Cited
1989
Thyroid hormones regulate rat thyrotropin beta gene promoter activity expressed in GH3 cells.
Thyroid hormones suppress the synthesis of TSH in part by decreasing the rate of alpha and TSH beta gene transcription. Cis… 
Highly Cited
1986
Highly Cited
1986
Foreign DNA introduced by calcium phosphate is integrated into repetitive DNA elements of the mouse L cell genome
We investigated the sites of integration of exogenous DNA fragments introduced by DNA-mediated gene transfer. Mouse Ltk- cells… 
Highly Cited
1984
Highly Cited
1984
Short-term, high-efficiency expression of transfected DNA
We have achieved high-efficiency uptake and expression of foreign DNA in mouse Ltk- cells by modifying the DEAE-dextran-mediated… 
Highly Cited
1983
Highly Cited
1983
E1A control of gene expression is mediated by sequences 5' to the transcriptional starts of the early viral genes
A product of the adenovirus E1A gene is a positive regulator of early viral gene expression. In this report we show that E1A… 
Highly Cited
1983
Highly Cited
1983
Recombination during gene transfer into mouse cells can restore the function of deleted genes.
Two plasmids containing nonoverlapping deletions of the herpes simplex virus thymidine kinase gene were introduced into thymidine… 
Highly Cited
1982
Highly Cited
1982
Stable expression in mouse cells of nuclear neoantigen after transfer of a 3.4-megadalton cloned fragment of Epstein-Barr virus DNA.
All cells that harbor the Epstein-Barr virus (EBV) genome contain a neoantigen in the nucleus (EBNA). By transfection we located… 
Highly Cited
1982
Highly Cited
1982
Adaptation of a retrovirus as a eucaryotic vector transmitting the herpes simplex virus thymidine kinase gene
We investigated the feasibility of using retroviruses as vectors for transferring DNA sequences into animal cells. The thymidine… 
Highly Cited
1981
Highly Cited
1981
Deoxyribonucleic acid-mediated gene transfer in mammalian cells: molecular analysis of unstable transformants and their progression to stability
To elucidate mechanisms involved in deoxyribonucleic acid-mediated gene transfer, we transferred the herpes simplex virus… 
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