HSV-Tk Gene

Known as: HSV-Tk, Herpes Simplex Virus Thymidine Kinase Gene 
Herpes simplex virus thymidine kinase (HSV-Tk) gene encodes thymidine kinase protein, which is important for herpes simplex virus infection. The TK… (More)
National Institutes of Health

Papers overview

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2003
2003
The first large randomized phase III trial in gene therapy demonstrated no improvement in the survival of patients injected with… (More)
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Highly Cited
2000
Highly Cited
2000
Between December 1996 and September 1998, 13 patients with advanced recurrent malignant brain tumors (9 with glioblastoma… (More)
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1999
Highly Cited
1999
For patients with local recurrence of prostate cancer after definitive irradiation therapy there is no treatment widely… (More)
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1994
Highly Cited
1994
A carcinoembryonic antigen (CEA)-producing human lung cancer cell line (A549), a nonproducing human lung cancer cell line (CADO… (More)
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Highly Cited
1994
Highly Cited
1994
Restenosis, a process characterized in part by excessive smooth muscle cell (SMC) proliferation in areas of vascular injury… (More)
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Highly Cited
1991
Highly Cited
1991
The thymidine kinase gene (tk) of herpes simplex type 1 virus (HSV-1) was inserted into a retroviral vector under the… (More)
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Highly Cited
1987
Highly Cited
1987
Inhibition of herpes simplex virus (HSV) thymidine kinase (TK) gene transcription (pHSV-106, pML-BPV-TK4) by DNA methylation is… (More)
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Highly Cited
1983
Highly Cited
1983
We have studied the effect of DNA methylation on human gamma-globin gene expression, using a novel in vitro DNA methylation… (More)
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Highly Cited
1982
Highly Cited
1982
We have constructed recombinant vaccinia viruses containing the thymidine kinase gene from herpes simplex virus. The gene was… (More)
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Highly Cited
1980
Highly Cited
1980
This paper presents the nucleotide sequence of the Herpes Simplex Virus thymidine kinase (tk) gene. The position on the DNA… (More)
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