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HSV-Tk Gene

Known as: HSV-Tk, Herpes Simplex Virus Thymidine Kinase Gene 
Herpes simplex virus thymidine kinase (HSV-Tk) gene encodes thymidine kinase protein, which is important for herpes simplex virus infection. The TK… 
National Institutes of Health

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Related topics

3 relations
PhosphorylationSimplexvirusVirus Physiological Phenomena

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1999
Highly Cited
1999
In situ gene therapy for adenocarcinoma of the prostate: a phase I clinical trial.
For patients with local recurrence of prostate cancer after definitive irradiation therapy there is no treatment widely… 
Highly Cited
1996
Highly Cited
1996
Gene therapy for α‐fetoprotein‐producing human hepatoma cells by adenovirus‐mediated transfer of the herpes simplex virus thymidine kinase gene
We have developed a recombinant replication‐defective adenovirus containing human α‐fetoprotein (AFP) promoter/enhancer to direct… 
Highly Cited
1994
Highly Cited
1994
Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene.
Highly Cited
1987
Highly Cited
1987
A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression.
To define the recognition sequence of the glucocorticoid receptor and its relationship with that of the progesterone receptor… 
Highly Cited
1984
Highly Cited
1984
Short-term, high-efficiency expression of transfected DNA
We have achieved high-efficiency uptake and expression of foreign DNA in mouse Ltk- cells by modifying the DEAE-dextran-mediated… 
Highly Cited
1983
Highly Cited
1983
DNA methylation and the regulation of globin gene expression
Highly Cited
1983
Highly Cited
1983
E1A control of gene expression is mediated by sequences 5' to the transcriptional starts of the early viral genes
A product of the adenovirus E1A gene is a positive regulator of early viral gene expression. In this report we show that E1A… 
Highly Cited
1983
Highly Cited
1983
A small region of the mouse mammary tumor virus long terminal repeat confers glucocorticoid hormone regulation on a linked heterologous gene.
Expression of mouse mammary tumor virus (MMTV) proviruses is transcriptionally regulated by glucocorticoid hormones. We have… 
Highly Cited
1982
Highly Cited
1982
Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus.
We have constructed recombinant vaccinia viruses containing the thymidine kinase gene from herpes simplex virus. The gene was… 
Highly Cited
1980
Highly Cited
1980
The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene.
This paper presents the nucleotide sequence of the Herpes Simplex Virus thymidine kinase (tk) gene. The position on the DNA… 
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