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HSD17B1 gene

Known as: MGC138140, short chain dehydrogenase/reductase family 28CE, member 1, hydroxysteroid (17-beta) dehydrogenase 1 
This gene is involved in estrogen biosynthesis.
National Institutes of Health

Related topics

Related topics

4 relations
HSD17B1 protein, humanHSD17B2 geneHSD17B4 geneOxidation-Reduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Association of endometriosis risk and genetic polymorphisms involving biosynthesis of sex steroids and their receptors: an updating meta-analysis.
2011
2011
Butyrate induces expression of 17β-hydroxysteroid dehydrogenase type 1 in HT29 and SW707 colorectal cancer cells.
Epidemiological studies have revealed that butyrate and 17β-estradiol (E2) may decrease the incidence of colorectal cancer (CRC… 
2008
2008
HSD17B1 Genetic Variants and Hormone Receptor–Defined Breast Cancer
HSD17B1 is an important candidate gene in breast cancer via its role in converting estrone to estradiol. A nonsynonymous G-to-A… 
2007
2007
Activation of androgens by hydroxysteroid (17beta) dehydrogenase 1 in vivo as a cause of prenatal masculinization and ovarian benign serous cystadenomas.
Hydroxysteroid (17beta) dehydrogenases (HSD17Bs) belong to the short-chain dehydrogenase/reductase family consisting of a diverse… 
Highly Cited
2006
Highly Cited
2006
Human hydroxysteroid (17-beta) dehydrogenase 1 expression enhances estrogen sensitivity of MCF-7 breast cancer cell xenografts.
Hydroxysteroid (17-beta) dehydrogenase 1 (HSD17B1) catalyzes the conversion between estrone (E1) and estradiol (E2). The reaction… 
Highly Cited
2004
Highly Cited
2004
HSD17B1 Gene Polymorphisms and Risk of Endometrial and Breast Cancer
Estrogen exposure influences breast and endometrial cancer risk. The HSD17B1 gene produces an enzyme that catalyzes the… 
2004
2004
DNA microarray-based analysis of single nucleotide polymorphisms may be useful for assessing the risks and benefits of hormone therapy.
Highly Cited
2003
Highly Cited
2003
HSD17B1 and CYP17 polymorphisms and breast cancer risk among Chinese women in Singapore
Reasons for the recent trend of increasing breast cancer incidence among Chinese and other Asian women are not well understood… 
1997
1997
Retinoic Acids Increase 17 (cid:98) -Hydroxysteroid Dehydrogenase Type 1 Expression in JEG-3 and T47D Cells, but the Stimulation Is Potentiated by Epidermal Growth Factor, 12-O -Tetradecanoylphorbol…
Human 17 (cid:98) -hydroxysteroid dehydrogenase type 1 (17HSD type 1) primarily catalyzes the reduction of low activity estrone… 
1994
1994
Human familial and sporadic breast cancer: analysis of the coding regions of the 17β-hydroxysteroid dehydrogenase 2 gene (EDH17B2) using a single-strand conformation polymorphism assay
Abstract17β-Hydroxysteroid dehydrogenase (17HSD) is one of the key enzymes in estrogen metabolism, catalyzing the reversible… 
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