HPGD wt Allele

Known as: 15-PGDH, Hydroxyprostaglandin Dehydrogenase 15-(NAD) wt Allele, PHOAR1 
Human HPGD wild-type allele is located within 4q34-q35 and is approximately 32 kb in length. This allele, which encodes 15-hydroxyprostaglandin… (More)
National Institutes of Health

Related topics

Related topics

8 relations
15-Hydroxyprostaglandin Dehydrogenase [NAD+], human15-Hydroxyprostaglandin dehydrogenase (NAD+)4q34-q35Eicosanoid Modulation
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Broader (1)

HPGD gene

Papers overview

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2010
2010
Loss of 15-hydroxyprostaglandin dehydrogenase expression contributes to bladder cancer progression.
Prostaglandin E2, which is known to contribute to cancer progression, is inactivated by the catabolic enzyme, 15… (More)
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2008
2008
Expression of 15-PGDH is downregulated by COX-2 in gastric cancer.
To explore the proteins regulated by cyclooxygenase-2 (COX-2) in gastric cancer, the expression plasmid of COX-2siRNA was… (More)
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2005
2005
Unique suppression of prostaglandin H synthase-2 expression by inhibition of histone deacetylation, specifically in human amnion but not adjacent choriodecidua.
The key molecular regulatory mechanisms that govern and coordinate the molecular alterations that underpin the process of human… (More)
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Highly Cited
2003
Highly Cited
2003
Bacterially-induced preterm labor and regulation of prostaglandin-metabolizing enzyme expression in mice: the role of toll-like receptor 4.
Toll-like receptor 4 (TLR-4) is a critical mediator of the cellular response to lipopolysaccharide. Our purpose was to examine… (More)
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2002
2002
Differential changes in 15-hydroxyprostaglandin dehydrogenase and prostaglandin H synthase (types I and II) in human pregnant myometrium.
Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical… (More)
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Review
2001
Review
2001
Understanding preterm labor.
Increased uterine contractility at term and preterm results from activation and then stimulation of the myometrium. Activation… (More)
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2000
2000
The human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene promoter is controlled by Ets and activating protein-1 transcription factors and progesterone.
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) is a key catabolic enzyme in the inactivation of PGF2alpha and PGE2… (More)
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Review
1999
Review
1999
Prostaglandin dehydrogenase and the initiation of labor.
In summary, these studies have suggested that prostaglandin dehydrogenase may have a central role to play in the mechanisms which… (More)
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1999
1999
Steroid regulation of prostaglandin dehydrogenase activity and expression in human term placenta and chorio-decidua in relation to labor.
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) is the key catabolic enzyme controlling levels of biologically active… (More)
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1997
1997
Chorionic prostaglandin catabolism is decreased in the lower uterine segment with term labour.
We have examined the hypothesis that regional differences in 15-hydroxyprostaglandin dehydrogenase (PGDH) activities occur within… (More)
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