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HPGD wt Allele

Known as: 15-PGDH, Hydroxyprostaglandin Dehydrogenase 15-(NAD) wt Allele, PHOAR1 
Human HPGD wild-type allele is located within 4q34-q35 and is approximately 32 kb in length. This allele, which encodes 15-hydroxyprostaglandin… 
National Institutes of Health

Related topics

Related topics

8 relations
15-Hydroxyprostaglandin Dehydrogenase [NAD+], human15-Hydroxyprostaglandin dehydrogenase (NAD+)4q34-q35Eicosanoid Modulation
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Broader (1)

HPGD gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Loss of 15-hydroxyprostaglandin dehydrogenase expression contributes to bladder cancer progression.
Prostaglandin E2, which is known to contribute to cancer progression, is inactivated by the catabolic enzyme, 15… 
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2005
2005
D-3-Phosphoglycerate Dehydrogenase from Mycobacterium tuberculosis Is a Link between the Escherichia coli and Mammalian Enzymes*
d-3-Phosphoglycerate dehydrogenase (PGDH) from Mycobacterium tuberculosis has been isolated to homogeneity and displays an… 
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Highly Cited
2003
Highly Cited
2003
Bacterially-Induced Preterm Labor and Regulation of Prostaglandin-Metabolizing Enzyme Expression in Mice: The Role of Toll-Like Receptor 41
Abstract Toll-like receptor 4 (TLR-4) is a critical mediator of the cellular response to lipopolysaccharide. Our purpose was to… 
2003
2003
Genomic structure and transcriptional regulation of the human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene.
The NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) is a catabolic enzyme that controls the biological activities… 
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2002
2002
Differential changes in 15-hydroxyprostaglandin dehydrogenase and prostaglandin H synthase (types I and II) in human pregnant myometrium.
Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical… 
Review
2001
Review
2001
Understanding Preterm Labor
Increased uterine contractility at term and preterm results from activation and then stimulation of the myometrium. Activation… 
Highly Cited
2000
Highly Cited
2000
The human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene promoter is controlled by Ets and activating protein-1 transcription factors and progesterone.
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) is a key catabolic enzyme in the inactivation of PGF2alpha and PGE2… 
Highly Cited
1999
Highly Cited
1999
Steroid regulation of prostaglandin dehydrogenase activity and expression in human term placenta and chorio-decidua in relation to labor.
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) is the key catabolic enzyme controlling levels of biologically active… 
Review
1999
Review
1999
Prostaglandin dehydrogenase and the initiation of labor
Abstract In summary, these studies have suggested that prostaglandin dehydrogenase may have a central role to play in the… 
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Highly Cited
1997
Highly Cited
1997
Chorionic prostaglandin catabolism is decreased in the lower uterine segment with term labour.
We have examined the hypothesis that regional differences in 15-hydroxyprostaglandin dehydrogenase (PGDH) activities occur within… 
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