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HPGD wt Allele

Known as: 15-PGDH, Hydroxyprostaglandin Dehydrogenase 15-(NAD) wt Allele, PHOAR1 
Human HPGD wild-type allele is located within 4q34-q35 and is approximately 32 kb in length. This allele, which encodes 15-hydroxyprostaglandin… Expand
National Institutes of Health

Related topics

Related topics

8 relations
15-Hydroxyprostaglandin Dehydrogenase [NAD+], human15-Hydroxyprostaglandin dehydrogenase (NAD+)4q34-q35Eicosanoid Modulation
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Broader (1)

HPGD gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Loss of 15-hydroxyprostaglandin dehydrogenase expression contributes to bladder cancer progression.
Prostaglandin E2, which is known to contribute to cancer progression, is inactivated by the catabolic enzyme, 15… Expand
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2008
2008
Expression of 15-PGDH is downregulated by COX-2 in gastric cancer.
To explore the proteins regulated by cyclooxygenase-2 (COX-2) in gastric cancer, the expression plasmid of COX-2siRNA was… Expand
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2005
2005
D-3-Phosphoglycerate Dehydrogenase from Mycobacterium tuberculosis Is a Link between the Escherichia coli and Mammalian Enzymes*
d-3-Phosphoglycerate dehydrogenase (PGDH) from Mycobacterium tuberculosis has been isolated to homogeneity and displays an… Expand
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Highly Cited
2003
Highly Cited
2003
Bacterially-Induced Preterm Labor and Regulation of Prostaglandin-Metabolizing Enzyme Expression in Mice: The Role of Toll-Like Receptor 41
Abstract Toll-like receptor 4 (TLR-4) is a critical mediator of the cellular response to lipopolysaccharide. Our purpose was to… Expand
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2002
2002
Differential changes in 15-hydroxyprostaglandin dehydrogenase and prostaglandin H synthase (types I and II) in human pregnant myometrium.
Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical… Expand
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Review
2001
Review
2001
Understanding Preterm Labor
Increased uterine contractility at term and preterm results from activation and then stimulation of the myometrium. Activation… Expand
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Highly Cited
2000
Highly Cited
2000
The human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene promoter is controlled by Ets and activating protein-1 transcription factors and progesterone.
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) is a key catabolic enzyme in the inactivation of PGF2alpha and PGE2… Expand
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Highly Cited
1999
Highly Cited
1999
Steroid regulation of prostaglandin dehydrogenase activity and expression in human term placenta and chorio-decidua in relation to labor.
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) is the key catabolic enzyme controlling levels of biologically active… Expand
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Review
1999
Review
1999
Prostaglandin dehydrogenase and the initiation of labor
Abstract In summary, these studies have suggested that prostaglandin dehydrogenase may have a central role to play in the… Expand
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Highly Cited
1997
Highly Cited
1997
Chorionic prostaglandin catabolism is decreased in the lower uterine segment with term labour.
We have examined the hypothesis that regional differences in 15-hydroxyprostaglandin dehydrogenase (PGDH) activities occur within… Expand
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