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HOXA@ gene cluster

Known as: HOX1@, HOX1, Hox-A 
A family of genes found in a cluster on the p arm of chromosome 7. These genes encode transcription factors that play a role in gene expression… 
National Institutes of Health

Related topics

Related topics

14 relations
Cell Differentiation processHomo sapiensPattern FormationTranscriptional Regulation

Broader (1)

Genes, Homeobox

Narrower (8)

HOXA1 geneHOXA11 geneHOXA13 geneHOXA2 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
An LSC epigenetic signature is largely mutation independent and implicates the HOXA cluster in AML pathogenesis
Acute myeloid leukaemia (AML) is characterized by subpopulations of leukaemia stem cells (LSCs) that are defined by their ability… 
Highly Cited
2013
Highly Cited
2013
Clustering of Tissue-Specific Sub-TADs Accompanies the Regulation of HoxA Genes in Developing Limbs
HoxA genes exhibit central roles during development and causal mutations have been found in several human syndromes including… 
Highly Cited
2009
Highly Cited
2009
Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells.
Highly Cited
2006
Highly Cited
2006
Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification
The oral-facial-digital type I (OFD1) syndrome (OMIM 311200) is a human developmental disorder; affected individuals have… 
Highly Cited
2005
Highly Cited
2005
HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL).
Using a combination of molecular cytogenetic and large-scale expression analysis in human T-cell acute lymphoblastic leukemias (T… 
Highly Cited
2005
Highly Cited
2005
Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function
Vertebrate HoxA and HoxD cluster genes are required for proper limb development. However, early lethality, compensation and… 
Review
2004
Review
2004
An Mll-Dependent Hox Program Drives Hematopoietic Progenitor Expansion
Highly Cited
1996
Highly Cited
1996
Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia
Expression of HoxaT and Hoxa9 is activated by proviral integration in BXH2 murine myeloid leukaemias. This result, combined with… 
Highly Cited
1996
Highly Cited
1996
Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity.
The Hox genes are involved in patterning along the A/P axes of animals. The clustered organization of Hox genes is conserved from… 
Highly Cited
1996
Highly Cited
1996
Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20.
The hindbrain is a segmented structure divided into repeating metameric units termed rhombomeres (r). The Hox family, vertebrate… 
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