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A Novel Superoxide-producing NAD(P)H Oxidase in Kidney*
TLDR
The present findings suggest that the novel NAD(P)H oxidase NOX4 may serve as an oxygen sensor and/or a regulator of cell growth in kidney, and possibly also play a role in cell proliferation and oxygen sensing for erythropoiesis. Expand
MafA Is a Glucose-regulated and Pancreatic β-Cell-specific Transcriptional Activator for the Insulin Gene*
TLDR
MafA is a β-cell-specific and glucose-regulated transcriptional activator for insulin gene expression and thus may be involved in the function and development of β-cells as well as in the pathogenesis of diabetes. Expand
Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases
TLDR
Human cDNAs encoding a novel member of Tob/BTG1 anti-proliferative family proteins were cloned and the amino-terminal half of Tob2 as well as that of Tob was associated with a human homologue of yeast Caf1, a component of the CCR4 transcription factor complex. Expand
Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family.
TLDR
The results suggest that the Wnt-13 gene may be involved in normal human development or differentiation as well as in human carcinogenesis. Expand
cDNA cloning of a novel bHLH-PAS transcription factor superfamily gene, BMAL2: its mRNA expression, subcellular distribution, and chromosomal localization.
TLDR
RNA analysis revealed that expression of BMAL2 transcripts was restricted to the fetal brain and to the adult liver in human, while human BMAL1 mRNA was expressed in the brain and skeletal Muscle. Expand
A gene outside the human MHC related to classical HLA class I genes.
TLDR
An expressed class I gene, MR1, has now been identified on human chromosome 1q25, outside the MHC, and encodes peptide-binding domains similar to those encoded by human leukocyte antigen (HLA)class I genes on chromosome 6 and by nonmammalian classical MHC class I genes. Expand
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones
TLDR
An exhaustive integrative characterization of 41,118 full-length cDNAs that capture the gene transcripts as complete functional cassettes is performed, providing an unequivocal report of structural and functional diversity at the gene level. Expand
Identification and Characterization of a Novel Family of Serine/Threonine Kinases Containing Two N-terminal LIM Motifs (*)
TLDR
Immunofluorescence and subcellular fractionation analysis revealed that Myc-tagged LIMK1 and LIMK2 were localized mainly in the cytoplasm, and a 140-kDa tyrosine-phosphorylated protein (pp140) may be a LimK1-associated protein involved in the regulation of LIMK 1 function. Expand
The genomic structure and expression of MJD, the Machado-Joseph disease gene
TLDR
Northern blot analysis showed that MJD mRNA is ubiquitously expressed in human tissues, and in at least four different sizes, which indicates that there are three alternative splicing sites and eight polyadenylation signals in MJD that are used to generate the differently sized transcripts. Expand
Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.
TLDR
Relatively large amounts of FZD 1 mRNA, 4.5 kb in size, were detected in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney, and the level of FzD7 mRNAs 5.0 and 4.0 kb in sizes was high in adult skeletal muscle and fetal kidney, followed by fetal lung,Adult heart, brain, and Placenta. Expand
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