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The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator
A Global Control Region Defines a Chromosomal Regulatory Landscape Containing the HoxD Cluster
Temporal colinearity and the phylotypic progression: a basis for the stability of a vertebrate Bauplan and the evolution of morphologies through heterochrony.
- D. Duboule
- BiologyDevelopment (Cambridge, England). Supplement
It is argued that temporal colinearity only occurs in cells with high mitotic rates, which results in a strong linkage between patterning and growth control and makes the patterning process unidirectional, from anterior, proximal and early, to posterior, distal and late, a model referred to as the 'Einbahnstrasse'.
The rise and fall of Hox gene clusters
- D. Duboule
- 15 July 2007
This work has shown that the bilaterian ancestor had a clustered Hox gene family and that, subsequently, this genomic organization was either maintained or lost.
A Dual Role for Hox Genes in Limb Anterior-Posterior Asymmetry
It is concluded that early posterior restriction of Hox gene products sets up an anterior-posterior prepattern, which determines the localized activation of Shh, and this signal is subsequently translated into digit morphological asymmetry by promoting the late expression ofHoxd genes.
Control of Hoxd genes' collinearity during early limb development.
Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs
Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation
Comparison of the expression patterns of the genes of Hox complexes in the early embryo suggests that similar molecular mechanisms are involved in the positional signalling along the axes of both the embryonic trunk and the fetal limbs.
A Switch Between Topological Domains Underlies HoxD Genes Collinearity in Mouse Limbs
It is shown that the early phase of transcription requires enhancers located in the telomeric gene desert, and the early and late phases of Hoxd gene transcription in limb buds are controlled by two opposite deserts flanking the cluster on either side and corresponding to two adjacent topological domains.
The Dynamic Architecture of Hox Gene Clusters
- D. Noordermeer, M. Leleu, E. Splinter, J. Rougemont, W. de Laat, D. Duboule
- 14 October 2011
Using high-resolution chromatin conformation capture methodology, this work examined the spatial configuration of Hox clusters in embryonic mouse tissues where different Hox genes are active and found that spatial compartmentalization may be key to process the colinear activation of these compact gene clusters.