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HOE 077

Known as: HOE-077 
National Institutes of Health

Related topics

Related topics

3 relations
CGP 3466omigapil

Broader (1)

lufironil

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2002
2002
Prolyl 4-hydroxylase inhibitor is more effective for the inhibition of proliferation than for inhibition of collagen synthesis of rat hepatic stellate cells.
1999
1999
Prolyl 4-hydroxylase inhibitor (HOE 077) prevents TIMP-1 gene expression in rat liver fibrosis
Abstract: The effects of a prolyl 4-hydroxylase inhibitor (HOE 077) on tissue inhibitor of metalloproteinase-1 (TIMP-1) and… 
1998
1998
Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females.
The perisinusoidal stellate cells of the liver in an injury milieu undergo activation, acquiring a myofibroblast-like phenotype… 
Highly Cited
1997
Highly Cited
1997
Prolyl 4-hydroxylase inhibitor (HOE 077) inhibits pig serum-induced rat liver fibrosis by preventing stellate cell activation.
1997
1997
Failure of a prolyl 4-hydroxylase inhibitor to alter extracellular matrix deposition during experimental pancreatitis.
In chronic pancreatitis the exocrine pancreatic tissue is replaced by extracellular matrix deposits from fibroblasts. We have… 
1995
1995
New prolyl 4‐hydroxylase inhibitor reduces procollagen gene expression and enzyme‐altered lesions in rat liver cirrhosis
A choline deficient l‐amino acid defined (CDAA) diet led to the development of liver cirrhosis in male Wistar rats after 16 weeks… 
1991
1991
Fibrosis of the liver in rats induced by bile duct ligation. Effects of inhibition by prolyl 4-hydroxylase.
1991
1991
Effects of the prolyl 4-hydroxylase proinhibitor HOE 077 on human and rat hepatocytes in primary culture.
1991
1991
Pharmacokinetics and metabolism of HOE 077. Preclinical studies.
Review
1991
Review
1991
General pharmacology, toxicology and future clinical development of HOE 077.
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