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Semaphorin 3A Is Required for Guidance of Olfactory Axons in Mice
It is shown that Sema3A expression by ensheathing cells plays an important role in guiding olfactory axons into specific compartments of the OB, and that aberrant axon trajectories are not corrected during development and that connections are made in inappropriate target regions. Expand
Developmental Profile and Sexually Dimorphic Expression of Kiss1 and Kiss1r in the Fetal Mouse Brain
The detection of immunoreactive KISS1 in perikarya of the ARC at E17 indicates that early mRNA is translated to peptide, which raises the possibility that gonadal hormones modulate the expression of Kiss1 in the ARC prior to birth. Expand
Peptide growth factor control of olfactory neurogenesis and neuron survival in vitro: Roles of EGF and TGF-βs
It is demonstrated that EGF acts as a mitogen for the basal cells that give rise to olfactory neurons and that transforming growth factor-beta s (TGF- beta s) promote neurogenesis. Expand
Fucose-containing glycolipids are stage- and region-specific antigens in developing embryonic brain of rodents.
In the mouse, immunocytochemical staining revealed that 7A antigen is expressed almost exclusively in germinal layers of the cerebral cortex beginning as early as day 11 of gestation and becomes undetectable by birth. Expand
Polysialic Acid Facilitates Migration of Luteinizing Hormone-Releasing Hormone Neurons on Vomeronasal Axons
Two types of evidence are provided that PSA-NCAM plays a role in LHRH cell migration: promotion of cell movement along the VNN tract that is sensitive to acute (enzymatic), but not chronic (genetic), and a preference of a subset of migrating L HRH cells for a PPA-positive axon branch over a PAA-negative branch in the NCAM-180 mutant. Expand
Expression of gamma-aminobutyric acid and gonadotropin-releasing hormone during neuronal migration through the olfactory system.
It is suggested that GABA may directly influence GnRH neuronal migration and development through migrational and trophic roles for GABA in development. Expand
Stromal Cell-Derived Factor-1 (Chemokine C-X-C Motif Ligand 12) and Chemokine C-X-C Motif Receptor 4 Are Required for Migration of Gonadotropin-Releasing Hormone Neurons to the Forebrain
It is shown here that stromal cell-derived factor-1 [SDF-1, also known as chemokine C-X-C motif ligand 12 (CXCL12)] is expressed in the embryonic nasal mesenchyme from as early as E10 in an increasing rostral to caudal gradient that is most intense at the border of the nasal meschyme and the telencephalon. Expand
Deleted in Colorectal Cancer (DCC) Regulates the Migration of Luteinizing Hormone-Releasing Hormone Neurons to the Basal Forebrain
LHRH neuron migration in DCC−/− mice is found to be abnormal and trajectories of the caudal vomeronasal nerve and positions of LHRH neurons are abnormal, consistent with the idea that DCC regulates the trajectory of a subset of vomer onasal axons that guide the migration of L HRH neurons. Expand
Minireview: recent progress in gonadotropin-releasing hormone neuronal migration.
It is likely that the multiple external factors converge on selective signal transduction pathways to engage the mechanical mechanisms needed to modulate GnRH neuronal movement and ultimately migration. Expand
Patterning of olfactory sensory connections is mediated by extracellular matrix proteins in the nerve layer of the olfactory bulb.
In early rat embryos when axons from sensory neurons first contact the olfactory bulb primordium, lactosamine-containing glycans (LCG) are detected on neurons that are broadly distributed within theExpand