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HIV Protease

Known as: p16 protease, HIV, HTLV-III Protease, HIV Protease [Chemical/Ingredient] 
Enzyme of the human immunodeficiency virus that is required for post-translational cleavage of gag and gag-pol precursor polyproteins into functional… 
National Institutes of Health

Related topics

Related topics

8 relations
In BloodProcess of secretionaspects of radiation effectschemical synthesis

Narrower (2)

p16 protease, Human immunodeficiency virus 1p16 protease, Human immunodeficiency virus 2

Papers overview

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2011
2011
Transmission of HIV drug resistance and non-B subtype distribution in the Spanish cohort of antiretroviral treatment naïve HIV-infected individuals (CoRIS).
Highly Cited
2010
Highly Cited
2010
Fragment‐Based Screen against HIV Protease
We have employed a fragment‐based screen against wild‐type (NL4‐3) HIV protease (PR) using the Active Sight fragment library and… 
Highly Cited
2007
Highly Cited
2007
Interflap distances in HIV-1 protease determined by pulsed EPR measurements.
Human immunodeficiency virus type 1 (HIV-1) protease, being responsible for the cleavage of the viral polyproteins gag and gag… 
2004
2004
Minor mutations in HIV protease at baseline and appearance of primary mutation 90M in patients for whom their first protease-inhibitor antiretroviral regimens failed.
The association between minor mutations in human immunodeficiency virus (HIV) protease at baseline and development of common… 
Highly Cited
1996
Highly Cited
1996
Anisotropic rotational diffusion of perdeuterated HIV protease from 15N NMR relaxation measurements at two magnetic fields
Summary15N NMR relaxation times in perdeuterated HIV-1 protease, complexed with the sub-nanomolar inhibitor DMP323, have been… 
Highly Cited
1996
Highly Cited
1996
A combined quantum/classical molecular dynamics study of the catalytic mechanism of HIV protease.
Based on available three-dimensional structures of enzyme-inhibitor complexes, the mechanism of the reaction catalysed by HIV… 
1996
1996
Cycloalkylpyranones and cycloalkyldihydropyrones as HIV protease inhibitors: exploring the impact of ring size on structure-activity relationships.
Previously, 3-substituted cycloalkylpyranones, such as 2d, have proven to be effective inhibitors of HIV protease. In an initial… 
Highly Cited
1990
Highly Cited
1990
Hydroxyethylamine analogues of the p17/p24 substrate cleavage site are tight-binding inhibitors of HIV protease.
We report the synthesis of hydroxyethylamine dipeptidyl isosteres that were designed to mimic the tetrahedral intermediate for… 
Highly Cited
1990
Highly Cited
1990
Processing, assembly, and immunogenicity of human immunodeficiency virus core antigens expressed by recombinant vaccinia virus.
Highly Cited
1988
Highly Cited
1988
In vivo and in vitro autoprocessing of human immunodeficiency virus protease expressed in Escherichia coli.
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