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HIF1alpha protein

Known as: Hypoxia-Inducible Factor 1, Alpha Subunit, bHLHe78, Class E Basic Helix-Loop-Helix Protein 78 
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted… 
National Institutes of Health

Related topics

Related topics

28 relations
Angiogenesis PathwayAngiogenic ProcessBasic Helix-Loop-Helix Transcription FactorsCellular Stress

Papers overview

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Highly Cited
2008
Highly Cited
2008
Regulation of hypoxia-inducible factor-1α by NF-κB
HIF (hypoxia-inducible factor) is the main transcription factor activated by low oxygen tensions. HIF-1α (and other α subunits… 
Review
2007
Review
2007
Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment
A large body of clinical evidence exists to suggest that tumor hypoxia negatively impacts radiotherapy. As a result, there has… 
Highly Cited
2003
Highly Cited
2003
Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor*
The hypoxia-inducible factors (HIFs) play a central role in oxygen homeostasis. Hydroxylation of one or two critical prolines by… 
Highly Cited
2003
Highly Cited
2003
Structural Basis of a Phototropin Light Switch
Phototropins are light-activated kinases important for plant responses to blue light. Light initiates signaling in these proteins… 
Highly Cited
2002
Highly Cited
2002
HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration
Erythropoietin (Epo) is upregulated by hypoxia and provides protection against apoptosis of erythroid progenitors in bone marrow… 
Highly Cited
2001
Highly Cited
2001
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity.
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls angiogenesis, erythropoiesis, and… 
Highly Cited
2000
Highly Cited
2000
Role of hypoxia‐inducible factor‐1 in hypoxia‐induced ischemic tolerance in neonatal rat brain
Hypoxia‐inducible factor‐1 (HIF‐1) is a heterodimer composed of HIF‐1α and HIF‐1β protein subunits. This transcription factor is… 
Highly Cited
1999
Highly Cited
1999
Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway*
HIF-1α (hypoxia-inducible factor 1α) is a basic-helix-loop-helix PAS (Per/Arnt/Sim) transcription factor that, under hypoxic… 
Highly Cited
1997
Highly Cited
1997
Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit*
Hypoxia-inducible factor-1 (HIF-1), a heterodimeric DNA binding complex composed of two basic-helix-loop-helix Per-AHR-ARNT-Sim… 
Review
1990
Review
1990
Object asymmetries in comparative Bantu syntax
ing away from the effects of the relative animacy of passivized subject and object markers, we see that object markers can… 
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