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HIF1alpha protein

Known as: Hypoxia-Inducible Factor 1, Alpha Subunit, bHLHe78, Class E Basic Helix-Loop-Helix Protein 78 
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted… 
National Institutes of Health

Related topics

Related topics

28 relations
Angiogenesis PathwayAngiogenic ProcessBasic Helix-Loop-Helix Transcription FactorsCellular Stress

Papers overview

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Highly Cited
2009
Highly Cited
2009
Inhibition of Contraction-Stimulated AMP-Activated Protein Kinase Inhibits Contraction-Stimulated Increases in PAS-TBC1D1 and Glucose Transport Without Altering PAS-AS160 in Rat Skeletal Muscle
OBJECTIVE Phosphorylation of two members of the TBC1 domain family of proteins, Akt substrate of 160 kDa (AS160, also known as… 
Highly Cited
2008
Highly Cited
2008
Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of Integrin-linked kinase (ILK)
Integrin-linked kinase (ILK) was assesed as a therapeutic target in glioblastoma xenograft models through multiple endpoints… 
Highly Cited
2008
Highly Cited
2008
Stem cell factor induces HIF-1alpha at normoxia in hematopoietic cells.
Highly Cited
2008
Highly Cited
2008
Involvement of asymmetric dimethylarginine (ADMA) in tubulointerstitial ischaemia in the early phase of diabetic nephropathy.
BACKGROUND Decreased peritubular capillary (PTC) flow due to impaired endothelial function elicits tubulointerstitial ischaemia… 
Highly Cited
2006
Highly Cited
2006
Design and synthesis of a series of novel pyrazolopyridines as HIF-1alpha prolyl hydroxylase inhibitors.
Highly Cited
2002
Highly Cited
2002
Storage of platelets in additive solutions: a pilot in vitro study of the effects of potassium and magnesium
Background and Objectives Platelet additive solutions (PAS) have been shown to be suitable for extended platelet storage but have… 
Highly Cited
2001
Highly Cited
2001
Relation of vascular endothelial growth factor production to expression and regulation of hypoxia-inducible factor-1 alpha and hypoxia-inducible factor-2 alpha in human bladder tumors and cell lines.
Hypoxia is an important regulator of vascular endothelial growth factor (VEGF) expression, and VEGF is associated with poor… 
Highly Cited
1998
Highly Cited
1998
Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: functional evidence for homology with mammalian HIF-1 alpha.
Hypoxia inducible factor-1 (HIF-1) is a heterodimeric complex of two basic-helix-loop-helix proteins of the PAS family which is… 
Highly Cited
1998
Highly Cited
1998
Up-regulation of hypoxia-inducible factor-1alpha is not sufficient for hypoxic/anoxic p53 induction.
Oxygen-deprived regions of a solid tumor can induce tumor suppressor p53 expression and hence select for p53-mutant tumor cells… 
Review
1997
Review
1997
Molecular aspects of oxygen sensing in physiological adaptation to hypoxia.
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