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Alveolar rhabdomyosarcoma is a pediatric soft-tissue sarcoma caused by PAX3/7-FOXO1 fusion oncogenes and is characterized by… Expand Hes genes, encoding basic helix-loop-helix (HLH) transcriptional repressors, are mammalian homologues of Drosophila hairy and… Expand Tumors exhibit complex organization and contain a variety of cell populations. The realization that the regenerative properties… Expand Notch signaling regulates intestinal development, homeostasis and tumorigenesis, but its precise downstream mechanism remains… Expand PURPOSE
Mastermind-like domain containing 1 (MAMLD1) is a causative gene for the fetal development of male external genitalia… Expand Notch signaling pathway maintains stem cells through transcriptional activation of HES/HEY family members to repress tissue… Expand Radial glial cells derive from neuroepithelial cells, and both cell types are identified as neural stem cells. Neural stem cells… Expand MMTV induces the mouse mammary tumor through the dysregulation of Notch, Wnt, or Fgf signaling pathway. Activation of Notch… Expand The isthmic organizer, which is located at the midbrain–hindbrain boundary, plays an essential role in development of the… Expand The Hes gene family members are mammalian homologues of the Drosophila hairy and Enhancer of split genes. hairy and Enhancer of… Expand