K. Gauthaman

Publications67
h-index26
Citations2,828
Highly Influential Citations98
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Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats.
TLDR
It is concluded that TT extract appears to possess aphrodisiac activity probably due to androgen increasing property of TT (observed in an earlier study on primates). Expand
Human Wharton’s Jelly Stem Cells Have Unique Transcriptome Profiles Compared to Human Embryonic Stem Cells and Other Mesenchymal Stem Cells
TLDR
The ability to modulate immune responses makes hWJSCs an important compatible stem cell source for transplantation therapy in allogeneic settings without immunorejection and provides a foundation for future functional studies where the exact mechanisms of these unique properties of hW JSCs can be confirmed. Expand
Separation of SSEA-4 and TRA-1–60 Labelled Undifferentiated Human Embryonic Stem Cells from A Heterogeneous Cell Population Using Magnetic-Activated Cell Sorting (MACS) and Fluorescence-Activated…
TLDR
Both hESCs and HepG2 cells in the ‘flow-through’ fraction following MACS separation were viable in culture whereas by FACS separation only the HepG 2 cells were viable, indicating that FACS efficiently helps to eliminate the undifferentiated h ESCs based on their cell-surface antigens expressed. Expand
Teratomas from pluripotent stem cells: A clinical hurdle
TLDR
This review addresses the issue of tumorigenesis and discusses approaches by which this concern may be overcome and emphasizes the need to concurrently explore alternative stem cell sources that do not confer the disadvantages of pluripotency but are widely multipotent so as to yield safe desirable tissues for clinical application as soon as possible. Expand
Derivation efficiency, cell proliferation, freeze-thaw survival, stem-cell properties and differentiation of human Wharton's jelly stem cells.
TLDR
It is proposed that human WJSC may be frozen at the same time as UCB in cord blood banks for regenerative medicine purposes. Expand
The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction--an evaluation using primates, rabbit and rat.
TLDR
TT increases some of the sex hormones, possibly due to the presence of protodioscin in the extract, and may be useful in mild to moderate cases of ED. Expand
Human umbilical cord wharton's jelly stem cell (hWJSC) extracts inhibit cancer cell growth in vitro
TLDR
Human Wharton's jelly stem cell extracts possess tumor inhibitory properties that are not specific to breast cancer cells alone and these effects are mediated via agents in its extracts. Expand
Taking stem cells to the clinic: Major challenges
TLDR
The hurdles all these stem cell types have to overcome before stem cell‐based therapy becomes a genuine reality are described in detail. Expand
Human umbilical cord wharton's jelly mesenchymal stem cells do not transform to tumor‐associated fibroblasts in the presence of breast and ovarian cancer cells unlike bone marrow mesenchymal stem…
TLDR
It is confirmed that hWJSCs do not transform to the TAF phenotype and may therefore not be associated with enhanced growth of solid tumors making them a safe MSC for cell based therapies. Expand
Human Umbilical Cord Wharton’s Jelly Stem Cells Undergo Enhanced Chondrogenic Differentiation when Grown on Nanofibrous Scaffolds and in a Sequential Two-stage Culture Medium Environment
TLDR
It is concluded that hWJSCs are an attractive stem cell source for inducing chondrogenesis in vitro when grown on nanoscaffolds and exposed sequentially first to complex medium and then followed byChondrogenic medium. Expand
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