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HDAC6 gene

Known as: JM21, protein phosphatase 1, regulatory subunit 90, KIAA0901 
This gene is involved in chromatin remodeling, repression of gene expression and cellular management of misfolded protein-induced stress.
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder due to selective loss of motor neurons… Expand
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Highly Cited
2012
Highly Cited
2012
Mesenchmal stem cells (MSCs) can be differentiated into either adipocytes or osteoblasts, and a reciprocal relationship exists… Expand
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Highly Cited
2011
Highly Cited
2011
Charcot-Marie-Tooth disease (CMT) is the most common inherited disorder of the peripheral nervous system. Mutations in the 27-kDa… Expand
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Highly Cited
2010
Highly Cited
2010
Histone deacetylase 6 (HDAC6) is structurally and functionally unique among the 11 human zinc-dependent histone deacetylases… Expand
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Highly Cited
2007
Highly Cited
2007
Genetic or pharmacological alteration of the activity of the histone deacetylase 6 (HDAC6) induces a parallel alteration in cell… Expand
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Highly Cited
2007
Highly Cited
2007
Sequestration of misfolded proteins into pericentriolar inclusions called aggresomes is a means that cells use to minimize… Expand
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Highly Cited
2005
Highly Cited
2005
The hydroxamic acid (HAA) analogue pan-histone deacetylase (HDAC) inhibitors (HDIs) LAQ824 and LBH589 have been shown to induce… Expand
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Highly Cited
2005
Highly Cited
2005
We have shown that the proteasome inhibitor bortezomib (formerly known as PS-341) triggers significant antitumor activity in… Expand
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Highly Cited
2003
Highly Cited
2003
Protein acetylation, especially histone acetylation, is the subject of both research and clinical investigation. At least four… Expand
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Highly Cited
2000
Highly Cited
2000
A backcrossed population (BC(4)F(2)) derived from a cross between a japonica rice variety, Nipponbare, as the recurrent parent… Expand
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