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HDAC6 gene

Known as: JM21, protein phosphatase 1, regulatory subunit 90, KIAA0901 
This gene is involved in chromatin remodeling, repression of gene expression and cellular management of misfolded protein-induced stress.
National Institutes of Health

Related topics

Related topics

7 relations
Cell Cycle ProgressionDevelopmental processHydrolysisTranscriptional Regulation

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HDAC6 wt Allele

Papers overview

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Highly Cited
2013
Highly Cited
2013
Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance
The accumulation of hyperphosphorylated tau in neurofibrillary tangles (NFTs) is a neuropathological hallmark of tauopathies… 
Highly Cited
2013
Highly Cited
2013
Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.
Hydroxamic acids were designed, synthesized, and evaluated for their ability to selectively inhibit human histone deacetylase 6… 
Highly Cited
2012
Highly Cited
2012
Upregulation of miR-22 promotes osteogenic differentiation and inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells by repressing HDAC6 protein expression.
Mesenchmal stem cells (MSCs) can be differentiated into either adipocytes or osteoblasts, and a reciprocal relationship exists… 
Highly Cited
2012
Highly Cited
2012
Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation
The abnormal accumulation of the microtubule-binding protein tau is associated with a number of neurodegenerative conditions, and… 
Highly Cited
2012
Highly Cited
2012
Parkin Ubiquitinates Tar-DNA Binding Protein-43 (TDP-43) and Promotes Its Cytosolic Accumulation via Interaction with Histone Deacetylase 6 (HDAC6)*
Background: TDP-43 pathology and the role of E3 ubiquitin ligases are increasingly recognized in neurodegeneration. Results… 
Highly Cited
2012
Highly Cited
2012
HDAC6 Inhibitor Blocks Amyloid Beta-Induced Impairment of Mitochondrial Transport in Hippocampal Neurons
Even though the disruption of axonal transport is an important pathophysiological factor in neurodegenerative diseases including… 
Highly Cited
2008
Highly Cited
2008
Ubiquitin Proteasome System Stress Underlies Synergistic Killing of Ovarian Cancer Cells by Bortezomib and a Novel HDAC6 Inhibitor
Purpose: Elevated metabolic activity of ovarian cancer cells causes increased ubiquitin-proteasome-system (UPS) stress, resulting… 
Highly Cited
2007
Highly Cited
2007
Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6
Sequestration of misfolded proteins into pericentriolar inclusions called aggresomes is a means that cells use to minimize… 
Highly Cited
2006
Highly Cited
2006
Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.
To find novel histone deacetylase 6 (HDAC6)-selective inhibitors and clarify the structural requirements for HDAC6-selective… 
Highly Cited
2000
Highly Cited
2000
Identification of heading date quantitative trait locus Hd6 and characterization of its epistatic interactions with Hd2 in rice using advanced backcross progeny.
A backcrossed population (BC(4)F(2)) derived from a cross between a japonica rice variety, Nipponbare, as the recurrent parent… 
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