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HCRT wt Allele

Known as: PPOX, OX, Hypocretin (Orexin) Neuropeptide Precursor wt Allele 
Human HCRT wild-type allele is located in the vicinity of 17q21 and is approximately 1 kb in length. This allele, which encodes orexin protein, plays… 
National Institutes of Health

Related topics

Related topics

4 relations
17q21Desire for foodG Protein-Coupled Receptor SignalingSynaptic Transmission

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Dan-Lou Prescription Inhibits Foam Cell Formation Induced by ox-LDL via the TLR4/NF-κB and PPARγ Signaling Pathways
Atherosclerosis is the major worldwide cause of mortality for patients with coronary heart disease. Many traditional Chinese… 
Review
2017
Review
2017
Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies.
2017
2017
MicroRNA-125a-5p alleviates the deleterious effects of ox-LDL on multiple functions of human brain microvessel endothelial cells.
MicroRNA-125a-5p (miR-125a-5p) could participate in the pathogenesis of vascular diseases. In this study, we investigated the… 
Highly Cited
2016
Highly Cited
2016
Oxidized Lipoprotein Uptake Through the CD36 Receptor Activates the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells
Purpose Accumulation of oxidized phospholipids/lipoproteins with age is suggested to contribute to the pathogenesis of AMD. We… 
Highly Cited
2004
Highly Cited
2004
Role of Caspases in Ox-LDL–Induced Apoptotic Cascade in Human Coronary Artery Endothelial Cells
Abstract— Oxidized low-density lipoprotein (ox-LDL) induces apoptosis in endothelial cells. However, steps leading to ox-LDL… 
Highly Cited
2003
Highly Cited
2003
LOX-1 Mediates Oxidized Low-Density Lipoprotein-Induced Expression of Matrix Metalloproteinases in Human Coronary Artery Endothelial Cells
Background—Oxidized LDL (ox-LDL) accumulation in the atherosclerotic region may enhance plaque instability. Both accumulation of… 
Highly Cited
2001
Highly Cited
2001
Reduced oxidized low-density lipoprotein after weight reduction in obese premenopausal women
BACKGROUND: Several studies support the hypothesis that oxidation of low-density lipoprotein (LDL) promotes atherogenesis… 
1999
1999
Oxidized low density lipoprotein suppresses expression of inducible cyclooxygenase in human macrophages.
Atherogenesis involves several aspects of chronic inflammation and wound healing. Indeed, the atheroma is considered a special… 
Highly Cited
1998
Highly Cited
1998
Identification and autoregulation of receptor for OX-LDL in cultured human coronary artery endothelial cells.
Although macrophages scavenge oxidatively modified low density lipoprotein (ox-LDL) via specific receptors, the uptake of ox-LDL… 
Highly Cited
1991
Highly Cited
1991
Stimulating effect of oxidized low density lipoproteins on plasminogen activator inhibitor-1 synthesis by endothelial cells.
Oxidized low density lipoproteins (ox-LDL) are thought to accelerate atherogenesis. It was recently demonstrated that patients… 
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