H3F3A gene

Known as: H3 Histone, Family 3A Gene, H3 histone, family 3A, H3F3A 
This gene is involved in chromatin structure.
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Diffuse intrinsic pontine glioma (DIPG) is the most severe paediatric solid tumour, with no significant therapeutic progress made… (More)
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Highly Cited
2013
Highly Cited
2013
It is recognized that some mutated cancer genes contribute to the development of many cancer types, whereas others are cancer… (More)
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Highly Cited
2013
Highly Cited
2013
H3F3A mutations are seen in ∼30% of pediatric glioblastoma (GBMs) and involve either the lysine residue at position 27 (K27M) or… (More)
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Highly Cited
2013
Highly Cited
2013
Recent studies have identified a Lys 27-to-methionine (K27M) mutation at one allele of H3F3A, one of the two genes encoding… (More)
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Highly Cited
2013
Highly Cited
2013
Sequencing of pediatric gliomas has identified missense mutations Lys27Met (K27M) and Gly34Arg/Val (G34R/V) in genes encoding… (More)
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Highly Cited
2013
Highly Cited
2013
The most common pediatric brain tumors are low-grade gliomas (LGGs). We used whole-genome sequencing to identify multiple new… (More)
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Highly Cited
2013
Highly Cited
2013
Recurrent mutations affecting the histone H3.3 residues Lys27 or indirectly Lys36 are frequent drivers of pediatric high-grade… (More)
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Highly Cited
2012
Highly Cited
2012
Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays considerable heterogeneity. We have recently… (More)
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Highly Cited
2012
Highly Cited
2012
Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However, DNA copy number and gene expression… (More)
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Highly Cited
2012
Highly Cited
2012
To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA… (More)
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