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The regulation of eukaryotic chromatin relies on interactions between many epigenetic factors, including histone modifications… Expand DNA double-strand breaks (DSBs) are acutely hazardous for cells, as they can cause genome instability. DSB repair involves the… Expand Eukaryotic chromatin is separated into functional domains differentiated by post-translational histone modifications, histone… Expand For a couple of decades the chromatin field has endured undeserved neglect. Indeed, what could be so exciting about a monotonous… Expand Many genes are recruited to the nuclear periphery upon transcriptional activation. The mechanism and functional significance of… Expand In yeast cells, H2A.Z regulates transcription and is globally associated within a few nucleosomes of the initiator regions of… Expand The histone variant H2A.Z plays an essential role in metazoans but its function remains to be determined. Here, we developed a… Expand The conserved histone variant H2A.Z functions in euchromatin to antagonize the spread of heterochromatin. The mechanism by which… Expand ABSTRACT Evolutionarily conserved variant histone H2A.Z has been recently shown to regulate gene transcription in Saccharomyces… Expand Fundamental to the process of mammalian development is the timed and coordinated regulation of gene expression. This requires… Expand