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The Transcriptional and Epigenomic Foundations of Ground State Pluripotency
Nitrite-driven anaerobic methane oxidation by oxygenic bacteria
Evidence for a fourth pathway to produce oxygen is presented, possibly of considerable geochemical and evolutionary importance, and opens up the possibility that oxygen was available to microbial metabolism before the evolution of oxygenic photosynthesis.
An Oestrogen Receptor α-bound Human Chromatin Interactome
It is proposed that chromatin interactions constitute a primary mechanism for regulating transcription in mammalian genomes and is described as a new strategy, chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) for the de novo detection of global Chromatin interactions.
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
- J. Kleinnijenhuis, J. Quintin, M. Netea
- Biology, MedicineProceedings of the National Academy of Sciences
- 17 September 2012
It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens.
Landscape of somatic mutations in 560 breast cancer whole genome sequences
This analysis of all classes of somatic mutation across exons, introns and intergenic regions highlights the repertoire of cancer genes and mutational processes operative, and progresses towards a comprehensive account of the somatic genetic basis of breast cancer.
Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers
Molecular mechanism of anaerobic ammonium oxidation
It is shown that N2H4 is produced from the anammox substrates ammonium and nitrite and that nitric oxide is the direct precursor of N2 H4, which presents a new biochemical reaction forging an N–N bond and fills a lacuna in understanding of the biochemical synthesis of the N2 in the atmosphere.
A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway