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The Transcriptional and Epigenomic Foundations of Ground State Pluripotency
TLDR
It is suggested that transcriptional potentiation and a permissive chromatin context characterize the ground state and that exit from it may not require a metastable intermediate or multilineage priming. Expand
Nitrite-driven anaerobic methane oxidation by oxygenic bacteria
TLDR
Evidence for a fourth pathway to produce oxygen is presented, possibly of considerable geochemical and evolutionary importance, and opens up the possibility that oxygen was available to microbial metabolism before the evolution of oxygenic photosynthesis. Expand
Landscape of somatic mutations in 560 breast cancer whole genome sequences
TLDR
This analysis of all classes of somatic mutation across exons, introns and intergenic regions highlights the repertoire of cancer genes and mutational processes operative, and progresses towards a comprehensive account of the somatic genetic basis of breast cancer. Expand
An Oestrogen Receptor α-bound Human Chromatin Interactome
TLDR
It is proposed that chromatin interactions constitute a primary mechanism for regulating transcription in mammalian genomes and is described as a new strategy, chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) for the de novo detection of global Chromatin interactions. Expand
Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
TLDR
This work uses promoter capture Hi-C to identify interacting regions of 31,253 promoters in 17 human primary hematopoietic cell types and shows that promoter interactions are highly cell type specific and enriched for links between active promoters and epigenetically marked enhancers. Expand
Molecular mechanism of anaerobic ammonium oxidation
TLDR
It is shown that N2H4 is produced from the anammox substrates ammonium and nitrite and that nitric oxide is the direct precursor of N2 H4, which presents a new biochemical reaction forging an N–N bond and fills a lacuna in understanding of the biochemical synthesis of the N2 in the atmosphere. Expand
Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
TLDR
It is shown that bacille Calmette-Guérin (BCG) vaccination in healthy volunteers led to a four- to sevenfold increase in the production of IFN-γ, but also to a twofold enhanced release of monocyte-derived cytokines, such as TNF and IL-1β, in response to unrelated bacterial and fungal pathogens. Expand
A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.
TLDR
The deubiquitinase activity of the TFTC/STAGA HAT complex is necessary to counteract heterochromatin silencing and acts as a positive cofactor for activation by nuclear receptors in vivo. Expand
mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
TLDR
The identification of glycolysis as a fundamental process in trained immunity further highlights a key regulatory role for metabolism in innate host defense and defines a potential therapeutic target in both infectious and inflammatory diseases. Expand
Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis.
TLDR
This study uses chromatin immunoprecipitation combined with deep sequencing to generate genome-wide maps of PPARgamma and retinoid X receptor (RXR)-binding sites, and RNA polymerase II (RNAPII) occupancy at very high resolution throughout adipocyte differentiation of 3T3-L1 cells, and indicates that a hitherto unrecognized high number of adipocyte genes of distinctly regulated pathways are directly activated by PPARGamma:RxR. Expand
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