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Guanine Nucleotide Exchange Factors

Known as: Guanine Nucleotide Releasing Factor, Guanine-Nucleotide-Releasing Factor, GDP GTP exchange factor 
Proteins that catalyze the release and exchange of GDP for GTP from GTP-binding regulatory proteins, which are active in the GTP-bound form.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
We currently reported that Vav2, a member of the guanine nucleotide exchange factor-Vav subfamily, participates in homocysteine… 
Highly Cited
2001
Highly Cited
2001
Rho GTPases are activated by a family of guanine nucleotide exchange factors (GEFs) known as Dbl family proteins. The structural… 
Highly Cited
2001
Highly Cited
2001
Epac1 is a Rap-specific guanine-nucleotide exchange factor (GEF) which is activated by the binding of cAMP to a cyclic nucleotide… 
Highly Cited
2000
Highly Cited
2000
Previous pharmacologic and genetic studies have demonstrated a critical role for the low molecular weight GTP-binding protein… 
Highly Cited
2000
Highly Cited
2000
ADP-ribosylation factors (ARFs) constitute a family of structurally related proteins that forms a subset of the Ras superfamily… 
Highly Cited
1997
Highly Cited
1997
Conversion of Ras proteins into an activated GTP-bound state able to bind effector proteins is catalyzed by specific guanine… 
Highly Cited
1993
Highly Cited
1993
A number of growth factors, including insulin and epidermal growth factor (EGF), induce accumulation of the GTP-bound form of… 
Highly Cited
1987
Highly Cited
1987
Previously, we have shown that phosphorylation of the eukaryotic initiation factor eIF-2 alpha increases under several… 
Highly Cited
1980
Highly Cited
1980
Guanine nucleotides selectively decrease binding of the agonist ligands [3H]clonidine and [3H]epinephrine to α2‐noradrenergic…