Guanine Nucleotide Exchange Factors

Known as: Guanine Nucleotide Releasing Factor, Guanine-Nucleotide-Releasing Factor, GDP GTP exchange factor 
Proteins that catalyze the release and exchange of GDP for GTP from GTP-binding regulatory proteins, which are active in the GTP-bound form.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Chlamydia trachomatis attachment to cells induces the secretion of the elementary body-associated protein TARP (Translocated… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Eukaryotic cells mobilize the actin cytoskeleton to generate a remarkable diversity of morphological behaviours, including… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
The Ras-related GTPase Rap1 stimulates integrin-mediated adhesion and spreading in various mammalian cell types. Here, we… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2002
Highly Cited
2002
The intracellular pathogen Legionella pneumophila subverts vesicle traffic in eukaryotic host cells to create a vacuole that… (More)
Is this relevant?
Review
2001
Review
2001
  • Yi Zheng
  • Trends in biochemical sciences
  • 2001
The Dbl family of guanine nucleotide exchange factors are multifunctional molecules that transduce diverse intracellular signals… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Eph receptors transduce short-range repulsive signals for axon guidance by modulating actin dynamics within growth cones. We… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) are neurodegenerative conditions that affect large motor… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Rap1 is a small, Ras-like GTPase that was first identified as a protein that could suppress the oncogenic transformation of cells… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1993
Highly Cited
1993
A human complementary DNA was isolated that encodes a widely expressed protein, hSos1, that is closely related to Sos, the… (More)
Is this relevant?
Highly Cited
1991
Highly Cited
1991
We have conducted a genetic screen for mutations that decrease the effectiveness of signaling by a protein tyrosine kinase, the… (More)
Is this relevant?