Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Guanine Nucleotide Exchange Factors

Known as: Guanine Nucleotide Releasing Factor, Guanine-Nucleotide-Releasing Factor, GDP GTP exchange factor 
Proteins that catalyze the release and exchange of GDP for GTP from GTP-binding regulatory proteins, which are active in the GTP-bound form.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Rac and Cdc42 are small GTPases that have been linked to multiple human cancers and are implicated in epithelial to mesenchymal… Expand
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Regulation of the actin cytoskeleton by microtubules is mediated by the Rho family GTPases. However, the molecular mechanisms… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2001
Review
2001
  • Y. Zheng
  • Trends in biochemical sciences
  • 2001
  • Corpus ID: 45755372
The Dbl family of guanine nucleotide exchange factors are multifunctional molecules that transduce diverse intracellular signals… Expand
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) are neurodegenerative conditions that affect large motor… Expand
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Eph receptors transduce short-range repulsive signals for axon guidance by modulating actin dynamics within growth cones. We… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Rap1 is a small, Ras-like GTPase that was first identified as a protein that could suppress the oncogenic transformation of cells… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1998
Highly Cited
1998
The PAK family of kinases are regulated through interaction with the small GTPases Cdc42 and Rac1, but little is known of the… Expand
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Signaling pathways that link extracellular factors to activation of the monomeric guanosine triphosphatase (GTPase) Rho control… Expand
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Antisera against murine Son of sevenless (Sos) recognize a protein of M(r) 155,000 in rat-1 fibroblasts with specific guanine… Expand
Is this relevant?
Highly Cited
1991
Highly Cited
1991
We have conducted a genetic screen for mutations that decrease the effectiveness of signaling by a protein tyrosine kinase, the… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?