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Guanine Nucleotide Exchange Factors
Known as:
Guanine Nucleotide Releasing Factor
, Guanine-Nucleotide-Releasing Factor
, GDP GTP exchange factor
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Proteins that catalyze the release and exchange of GDP for GTP from GTP-binding regulatory proteins, which are active in the GTP-bound form.
National Institutes of Health
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Related topics
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50 relations
ARHGEF1 gene
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ARHGEF11 protein, mouse
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Broader (1)
GTP-Binding Proteins
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Contribution of Guanine Nucleotide Exchange Factor Vav2 to Hyperhomocysteinemic Glomerulosclerosis in Rats
Fan Yi
,
M. Xia
,
Ningjun Li
,
Chun Zhang
,
Lin Tang
,
Pin-Lan Li
HYPERTENSION
2009
Corpus ID: 13258378
We currently reported that Vav2, a member of the guanine nucleotide exchange factor-Vav subfamily, participates in homocysteine…
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Highly Cited
2001
Highly Cited
2001
Molecular basis for Rac1 recognition by guanine nucleotide exchange factors
A. Karnoub
,
D. Worthylake
,
+4 authors
C. Der
Nature Structural Biology
2001
Corpus ID: 12906996
Rho GTPases are activated by a family of guanine nucleotide exchange factors (GEFs) known as Dbl family proteins. The structural…
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Highly Cited
2001
Highly Cited
2001
Dynamic interaction of cAMP with the Rap guanine-nucleotide exchange factor Epac1.
R. Cool
,
Astrid Kraemer
,
+4 authors
Alfred Wittinghofer
Journal of Molecular Biology
2001
Corpus ID: 33686032
Epac1 is a Rap-specific guanine-nucleotide exchange factor (GEF) which is activated by the binding of cAMP to a cyclic nucleotide…
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Highly Cited
2000
Highly Cited
2000
The Rho Family Guanine Nucleotide Exchange Factor Vav-2 Regulates the Development of Cell-Mediated Cytotoxicity
D. Billadeau
,
Stacy M. Mackie
,
R. A. Schoon
,
P. Leibson
Journal of Experimental Medicine
2000
Corpus ID: 17173093
Previous pharmacologic and genetic studies have demonstrated a critical role for the low molecular weight GTP-binding protein…
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Highly Cited
2000
Highly Cited
2000
Identification of a Plasma Membrane-associated Guanine Nucleotide Exchange Factor for ARF6 in Chromaffin Cells
Anne‐Sophie Caumont
,
N. Vitale
,
M. Gensse
,
M. Galas
,
J. Casanova
,
M. Bader
Journal of Biological Chemistry
2000
Corpus ID: 25900800
ADP-ribosylation factors (ARFs) constitute a family of structurally related proteins that forms a subset of the Ras superfamily…
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Highly Cited
1997
Highly Cited
1997
Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras
N. P. Fam
,
W. Fan
,
Z. Wang
,
L. J. Zhang
,
H. Chen
,
M. Moran
Molecular and Cellular Biology
1997
Corpus ID: 21307470
Conversion of Ras proteins into an activated GTP-bound state able to bind effector proteins is catalyzed by specific guanine…
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Highly Cited
1993
Highly Cited
1993
Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras
René H. Medema
,
A. M. D. Vries-Smits
,
G. Zon
,
J. A. Maassen
,
Johannes L. Bos
Molecular and Cellular Biology
1993
Corpus ID: 26092576
A number of growth factors, including insulin and epidermal growth factor (EGF), induce accumulation of the GTP-bound form of…
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Highly Cited
1993
Highly Cited
1993
Kinetics of interaction between normal and proline 12 Ras and the GTPase-activating proteins, p120-GAP and neurofibromin. The significance of the intrinsic GTPase rate in determining the transforming…
J. Eccleston
,
K. J. Moore
,
L. Morgan
,
R. Skinner
,
P. N. Lowe
Journal of Biological Chemistry
1993
Corpus ID: 40211063
Highly Cited
1987
Highly Cited
1987
Physiological stresses inhibit guanine-nucleotide-exchange factor in Ehrlich cells.
A. Rowlands
,
K. Montine
,
E. Henshaw
,
R. Panniers
European Journal of Biochemistry
1987
Corpus ID: 5930266
Previously, we have shown that phosphorylation of the eukaryotic initiation factor eIF-2 alpha increases under several…
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Highly Cited
1980
Highly Cited
1980
Interactions of Divalent Cations and Guanine Nucleotides at α2‐Noradrenergic Receptor Binding Sites in Bovine Brain Mechanisms
D. U'prichard
,
S. Snyder
Journal of Neurochemistry
1980
Corpus ID: 26551560
Guanine nucleotides selectively decrease binding of the agonist ligands [3H]clonidine and [3H]epinephrine to α2‐noradrenergic…
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