Guanine Nucleotide Exchange Factors

Known as: Guanine Nucleotide Releasing Factor, Guanine-Nucleotide-Releasing Factor, GDP GTP exchange factor 
Proteins that catalyze the release and exchange of GDP for GTP from GTP-binding regulatory proteins, which are active in the GTP-bound form.
National Institutes of Health

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GTP-Binding Proteins

Papers overview

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Highly Cited
2008
Highly Cited
2008
Chlamydial Entry Involves TARP Binding of Guanine Nucleotide Exchange Factors
Chlamydia trachomatis attachment to cells induces the secretion of the elementary body-associated protein TARP (Translocated… (More)
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Highly Cited
2007
Highly Cited
2007
Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors
Eukaryotic cells mobilize the actin cytoskeleton to generate a remarkable diversity of morphological behaviours, including… (More)
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Highly Cited
2004
Highly Cited
2004
Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors
The Ras-related GTPase Rap1 stimulates integrin-mediated adhesion and spreading in various mammalian cell types. Here, we… (More)
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Highly Cited
2002
Highly Cited
2002
A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes.
The intracellular pathogen Legionella pneumophila subverts vesicle traffic in eukaryotic host cells to create a vacuole that… (More)
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Review
2001
Review
2001
Dbl family guanine nucleotide exchange factors.
  • Yi Zheng
  • Trends in biochemical sciences
  • 2001
The Dbl family of guanine nucleotide exchange factors are multifunctional molecules that transduce diverse intracellular signals… (More)
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Highly Cited
2001
Highly Cited
2001
EphA Receptors Regulate Growth Cone Dynamics through the Novel Guanine Nucleotide Exchange Factor Ephexin
Eph receptors transduce short-range repulsive signals for axon guidance by modulating actin dynamics within growth cones. We… (More)
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Highly Cited
2001
Highly Cited
2001
The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) are neurodegenerative conditions that affect large motor… (More)
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Highly Cited
1998
Highly Cited
1998
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
Rap1 is a small, Ras-like GTPase that was first identified as a protein that could suppress the oncogenic transformation of cells… (More)
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Highly Cited
1993
Highly Cited
1993
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
A human complementary DNA was isolated that encodes a widely expressed protein, hSos1, that is closely related to Sos, the… (More)
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Highly Cited
1991
Highly Cited
1991
Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase
We have conducted a genetic screen for mutations that decrease the effectiveness of signaling by a protein tyrosine kinase, the… (More)
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