Guanine Nucleotide Exchange Factors

Rac and Cdc42 are small GTPases that have been linked to multiple human cancers and are implicated in epithelial to mesenchymal… Expand

Regulation of the actin cytoskeleton by microtubules is mediated by the Rho family GTPases. However, the molecular mechanisms… Expand

The Dbl family of guanine nucleotide exchange factors are multifunctional molecules that transduce diverse intracellular signals… Expand

Amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) are neurodegenerative conditions that affect large motor… Expand

Eph receptors transduce short-range repulsive signals for axon guidance by modulating actin dynamics within growth cones. We… Expand

Rap1 is a small, Ras-like GTPase that was first identified as a protein that could suppress the oncogenic transformation of cells… Expand

The PAK family of kinases are regulated through interaction with the small GTPases Cdc42 and Rac1, but little is known of the… Expand

Signaling pathways that link extracellular factors to activation of the monomeric guanosine triphosphatase (GTPase) Rho control… Expand

Antisera against murine Son of sevenless (Sos) recognize a protein of M(r) 155,000 in rat-1 fibroblasts with specific guanine… Expand

We have conducted a genetic screen for mutations that decrease the effectiveness of signaling by a protein tyrosine kinase, the… Expand