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Guanazole

Known as: 1H-1,2,4-Triazole-3,5-Diamine, Guanazole [Chemical/Ingredient], 3,5-Diamino-1H-1,2,4-Triazole 
A cytostatic triazole derivative antimetabolite. Guanazole scavenges tyrosine free radicals, thereby inhibiting mammalian ribonucleotide reductase… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Nine members of a new anions-controlled Cd(II)-guanazole (3,5-diamino-1,2,4-triazole=Hdatrz) hybrid family, that is, [Cd3(datrz)6… Expand
Highly Cited
2005
Highly Cited
2005
Amitrole (ATz, 3-amino-1H-1,2,4-triazole) is a widely employed herbicide with strong estrogenic activity that can lead to… Expand
Highly Cited
2004
Highly Cited
2004
Urazole is α five-membered heterocyclic compound which is isosteric with uracil's hydrogen-bonding segment. Urazole reacts… Expand
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1981
1981
Nine amide derivatives of guanazole were synthesized, and eight of them were tested for antineoplastic activity versus L1210… Expand
1976
1976
Adults with previously treated acute nonlymphocytic leukemia received either 5‐azacytidine or guanazole in a randomized study… Expand
1975
1975
  • M. Paul, C. Dave
  • Proceedings of the Society for Experimental…
  • 1975
  • Corpus ID: 42910893
Summary A simplified technique for iv infusion in unrestricted DBA/2J inbred mice has been described. The method, which involves… Expand
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1974
1974
Hydroxyurea and guanazole were used as selective agents in tissue culture to obtain independent Chinese hamster ovary cell lines… Expand
1974
1974
Abstract Four Chinese hamster ovary cell lines and one mouse L cell line have been isolated which are resistant to the cytotoxic… Expand
Highly Cited
1972
Highly Cited
1972
The cell cycle specificity of chromatid breakage induced by inhibitors of DNA synthesis depends on the mechanism of drug action… Expand
Highly Cited
1970
Highly Cited
1970
Summary Guanazole (3,5-diamino-1,2,4-triazole; NSC 1895) was found to inhibit the incorporation of adenine, hypoxanthine, and… Expand