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Guanazole
Known as:
1H-1,2,4-Triazole-3,5-Diamine
, Guanazole [Chemical/Ingredient]
, 3,5-Diamino-1H-1,2,4-Triazole
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A cytostatic triazole derivative antimetabolite. Guanazole scavenges tyrosine free radicals, thereby inhibiting mammalian ribonucleotide reductase…
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National Institutes of Health
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Related topics
Related topics
8 relations
Broader (1)
Antineoplastic Agents
In Blood
agonists
analogs & derivatives
antagonists & inhibitors
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors.
Xin Zhao
,
Yanling Jie
,
+8 authors
Wenhui Hu
Antiviral research
2012
Corpus ID: 19187347
Highly Cited
2008
Highly Cited
2008
Synthesis, structure, and physical properties of a new anions-controlled Cd(II)-guanazole (3,5-diamino-1,2,4-triazole) hybrid family.
Rui-Bo Zhang
,
Z. Li
,
Y. Qin
,
Jian-Kai Cheng
,
Jian Zhang
,
Yuan-Gen Yao
Inorganic chemistry
2008
Corpus ID: 31126241
Nine members of a new anions-controlled Cd(II)-guanazole (3,5-diamino-1,2,4-triazole=Hdatrz) hybrid family, that is, [Cd3(datrz)6…
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Highly Cited
2005
Highly Cited
2005
Formation of refractory ring-expanded triazine intermediates during the photocatalyzed mineralization of the endocrine disruptor amitrole and related triazole derivatives at UV-irradiated TiO2/H2O…
N. Watanabe
,
S. Horikoshi
,
A. Kawasaki
,
H. Hidaka
,
N. Serpone
Environmental science & technology
2005
Corpus ID: 8998363
Amitrole (ATz, 3-amino-1H-1,2,4-triazole) is a widely employed herbicide with strong estrogenic activity that can lead to…
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Highly Cited
1982
Highly Cited
1982
Therapeutic response of leukemic mice treated with fluorinated pyrimidines and inhibitors of deoxyuridylate synthesis.
R. Moran
,
P. Danenberg
,
C. Heidelberger
Biochemical pharmacology
1982
Corpus ID: 40046827
Highly Cited
1981
Highly Cited
1981
Effect of iron-chelating agents on inhibitors of ribonucleotide reductase.
J. G. Cory
,
L. Lasater
,
A. Sato
Biochemical pharmacology
1981
Corpus ID: 34653303
1980
1980
Specific inhibition of the subunits of ribonucleotide reductase as a new approach to combination chemotherapy.
J. G. Cory
,
A. Sato
,
L. Lasater
Advances in enzyme regulation
1980
Corpus ID: 21812334
1976
1976
A comparative clinical trial of 5‐azacytidine and guanazole in previously treated adults with acute nonlymphocytic leukemia
J. Levi
,
P. Wiernik
Cancer
1976
Corpus ID: 34074407
Adults with previously treated acute nonlymphocytic leukemia received either 5‐azacytidine or guanazole in a randomized study…
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1974
1974
Altered ribonucleotide reductase activity in mammalian tissue culture cells resistant to hydroxyurea.
W. H. Lewis
,
J. Wright
Biochemical and biophysical research…
1974
Corpus ID: 37617956
1974
1974
Evidence of a common site of action for the antitumor agents, hydroxyurea and guanazole
J. Wright
,
W. H. Lewis
Journal of cellular physiology
1974
Corpus ID: 40899225
Hydroxyurea and guanazole were used as selective agents in tissue culture to obtain independent Chinese hamster ovary cell lines…
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Highly Cited
1970
Highly Cited
1970
Inhibition of ribonucleotide reductase, DNA synthesis, and L1210 leukemia by guanazole.
R. W. Brockman
,
S. Shaddix
,
W. R. Laster
,
F. Schabel
Cancer research
1970
Corpus ID: 45690722
Summary Guanazole (3,5-diamino-1,2,4-triazole; NSC 1895) was found to inhibit the incorporation of adenine, hypoxanthine, and…
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