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Guanazole

Known as: 1H-1,2,4-Triazole-3,5-Diamine, Guanazole [Chemical/Ingredient], 3,5-Diamino-1H-1,2,4-Triazole 
A cytostatic triazole derivative antimetabolite. Guanazole scavenges tyrosine free radicals, thereby inhibiting mammalian ribonucleotide reductase… Expand
National Institutes of Health

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8 relations

Broader (1)

Antineoplastic Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

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2008
2008
Synthesis, structure, and physical properties of a new anions-controlled Cd(II)-guanazole (3,5-diamino-1,2,4-triazole) hybrid family.
Nine members of a new anions-controlled Cd(II)-guanazole (3,5-diamino-1,2,4-triazole=Hdatrz) hybrid family, that is, [Cd3(datrz)6… Expand
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2007
2007
Integrated bioinformatic and phenotypic analysis of RpoN-dependent traits in the plant growth-promoting bacterium Pseudomonas fluorescens SBW25.
The alternative sigma factor RpoN is a key regulator in the acclimation of Pseudomonas to complex natural environments. In this… Expand
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2005
2005
Formation of refractory ring-expanded triazine intermediates during the photocatalyzed mineralization of the endocrine disruptor amitrole and related triazole derivatives at UV-irradiated TiO2/H2O…
Amitrole (ATz, 3-amino-1H-1,2,4-triazole) is a widely employed herbicide with strong estrogenic activity that can lead to… Expand
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1994
1994
Alternative bases in the RNA world: The prebiotic synthesis of urazole and its ribosides
Urazole is α five-membered heterocyclic compound which is isosteric with uracil's hydrogen-bonding segment. Urazole reacts… Expand
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1990
1990
DNA repair induced by various mutagens in rat hepatocyte primary cultures measured in the presence of hydroxyurea, guanazole or aphidicolin.
Guanazole and aphidicolin were chosen as candidates in the search for a selective, non-genotoxic inhibitor of DNA replication… Expand
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1980
1980
1,2-Diaminocyclohexane platinum derivatives of potential clinical value.
Cisdiamminodichloroplatinum (DDP) has assumed an important role in clinical cancer chemotherapy either alone or, more often, in… Expand
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1977
1977
Differential tumor immunogenicity of L1210 and its sublines. I. Effect of an increased antigen density on tumor cell surfaces on primary B cell responses in vitro.
The differential immunogenicity of DBA/2 lymphoma L1210 and three L1210 sublines, each resistant to a different anti-leukemic… Expand
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1976
1976
A comparative clinical trial of 5-azacytidine and guanazole in previously treated adults with acute nonlymphocytic leukemia.
Adults with previously treated acute nonlymphocytic leukemia received either 5-azacytidine or guanazole in a randomized study… Expand
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1975
1975
Selection for high immunogenicity in drug-resistant sublines of murine lymphomas demonstrated by plaque assay.
The immunogenicity of lymphoma L1210 and three L1210 sublines, resistant to methylglyoxal bis(guanylhydrazone), 4,4… Expand
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1970
1970
Inhibition of ribonucleotide reductase, DNA synthesis, and L1210 leukemia by guanazole.
Summary Guanazole (3,5-diamino-1,2,4-triazole; NSC 1895) was found to inhibit the incorporation of adenine, hypoxanthine, and… Expand
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