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Guanazole

Known as: 1H-1,2,4-Triazole-3,5-Diamine, Guanazole [Chemical/Ingredient], 3,5-Diamino-1H-1,2,4-Triazole 
A cytostatic triazole derivative antimetabolite. Guanazole scavenges tyrosine free radicals, thereby inhibiting mammalian ribonucleotide reductase… Expand
National Institutes of Health

Related topics

Related topics

8 relations

Broader (1)

Antineoplastic Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

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Highly Cited
2008
Highly Cited
2008
Synthesis, structure, and physical properties of a new anions-controlled Cd(II)-guanazole (3,5-diamino-1,2,4-triazole) hybrid family.
Nine members of a new anions-controlled Cd(II)-guanazole (3,5-diamino-1,2,4-triazole=Hdatrz) hybrid family, that is, [Cd3(datrz)6… Expand
Highly Cited
2005
Highly Cited
2005
Formation of refractory ring-expanded triazine intermediates during the photocatalyzed mineralization of the endocrine disruptor amitrole and related triazole derivatives at UV-irradiated TiO2/H2O…
Amitrole (ATz, 3-amino-1H-1,2,4-triazole) is a widely employed herbicide with strong estrogenic activity that can lead to… Expand
Highly Cited
2004
Highly Cited
2004
Alternative bases in the RNA world: The prebiotic synthesis of urazole and its ribosides
Urazole is α five-membered heterocyclic compound which is isosteric with uracil's hydrogen-bonding segment. Urazole reacts… Expand
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1981
1981
Synthesis and evaluation of guanazole prodrugs as antineoplastic agents.
Nine amide derivatives of guanazole were synthesized, and eight of them were tested for antineoplastic activity versus L1210… Expand
1976
1976
A comparative clinical trial of 5‐azacytidine and guanazole in previously treated adults with acute nonlymphocytic leukemia
Adults with previously treated acute nonlymphocytic leukemia received either 5‐azacytidine or guanazole in a randomized study… Expand
1975
1975
A Simple Method for Long-Term Drug Infusion in Mice: Evaluation of Guanazole as a Model 1
  • M. Paul, C. Dave
  • Proceedings of the Society for Experimental…
  • 1975
    • Corpus ID: 42910893
Summary A simplified technique for iv infusion in unrestricted DBA/2J inbred mice has been described. The method, which involves… Expand
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1974
1974
Evidence of a common site of action for the antitumor agents, hydroxyurea and guanazole
Hydroxyurea and guanazole were used as selective agents in tissue culture to obtain independent Chinese hamster ovary cell lines… Expand
1974
1974
Altered ribonucleotide reductase activity in mammalian tissue culture cells resistant to hydroxyurea.
Abstract Four Chinese hamster ovary cell lines and one mouse L cell line have been isolated which are resistant to the cytotoxic… Expand
Highly Cited
1972
Highly Cited
1972
Chromatid Breakage: Differential Effect of Inhibitors of DNA Synthesis during G2 Phase
The cell cycle specificity of chromatid breakage induced by inhibitors of DNA synthesis depends on the mechanism of drug action… Expand
Highly Cited
1970
Highly Cited
1970
Inhibition of ribonucleotide reductase, DNA synthesis, and L1210 leukemia by guanazole.
Summary Guanazole (3,5-diamino-1,2,4-triazole; NSC 1895) was found to inhibit the incorporation of adenine, hypoxanthine, and… Expand
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