Guanazole

Known as: Guanazole [Chemical/Ingredient], 3,5-Diamino-1H-1,2,4-Triazole, 1H-1,2,4-Triazole-3,5-diamine 
A cytostatic triazole derivative antimetabolite. Guanazole scavenges tyrosine free radicals, thereby inhibiting mammalian ribonucleotide reductase… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2014
02419702014

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2007
2007
The alternative sigma factor RpoN is a key regulator in the acclimation of Pseudomonas to complex natural environments. In this… (More)
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1994
1994
Urazole is α five-membered heterocyclic compound which is isosteric with uracil's hydrogen-bonding segment. Urazole reacts… (More)
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1990
1990
Guanazole and aphidicolin were chosen as candidates in the search for a selective, non-genotoxic inhibitor of DNA replication… (More)
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1982
1982
The therapeutic efficacy of combinations of fluorinated pyrimidines and inhibitors of either ribonucleotide reductase or… (More)
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1977
1977
The differential immunogenicity of DBA/2 lymphoma L1210 and three L1210 sublines, each resistant to a different anti-leukemic… (More)
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1976
1976
Adults with previously treated acute nonlymphocytic leukemia received either 5-azacytidine or guanazole in a randomized study… (More)
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1975
1975
A simplified technique for iv infusion in unrestricted DBA/2-J inbred mice has been described. The method, which involves direct… (More)
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1975
1975
Two dose schedules of guanazole were used in this phase I clinical study: intermittent prolonged 5-day infusion and intermittent… (More)
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1972
1972
The cell cycle specificity of chromatid breakage induced by inhibitors of DNA synthesis depends on the mechanism of drug action… (More)
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1970
1970
Guanazole (3,5-diamino-l,2,4-triazole; NSC 1895) was found to inhibit the incorporation of adenine, hypoxanthine, and uridine… (More)
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