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Guanazole

Known as: Guanazole [Chemical/Ingredient], 3,5-Diamino-1H-1,2,4-Triazole, 1H-1,2,4-Triazole-3,5-diamine 
A cytostatic triazole derivative antimetabolite. Guanazole scavenges tyrosine free radicals, thereby inhibiting mammalian ribonucleotide reductase… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2014
02419702014

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9 relations

Broader (1)

Antineoplastic Agents
In Bloodadministration & dosageagonistsantagonists & inhibitors
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Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
Guanazole
agonists
Antineoplastic Agents
chemical synthesis
standards characteristics
In Blood

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Integrated bioinformatic and phenotypic analysis of RpoN-dependent traits in the plant growth-promoting bacterium Pseudomonas fluorescens SBW25.
The alternative sigma factor RpoN is a key regulator in the acclimation of Pseudomonas to complex natural environments. In this… (More)
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1994
1994
Alternative bases in the RNA world: The prebiotic synthesis of urazole and its ribosides
Urazole is α five-membered heterocyclic compound which is isosteric with uracil's hydrogen-bonding segment. Urazole reacts… (More)
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1990
1990
DNA repair induced by various mutagens in rat hepatocyte primary cultures measured in the presence of hydroxyurea, guanazole or aphidicolin.
Guanazole and aphidicolin were chosen as candidates in the search for a selective, non-genotoxic inhibitor of DNA replication… (More)
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1982
1982
Therapeutic response of leukemic mice treated with fluorinated pyrimidines and inhibitors of deoxyuridylate synthesis.
The therapeutic efficacy of combinations of fluorinated pyrimidines and inhibitors of either ribonucleotide reductase or… (More)
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1977
1977
Differential tumor immunogenicity of L1210 and its sublines. I. Effect of an increased antigen density on tumor cell surfaces on primary B cell responses in vitro.
The differential immunogenicity of DBA/2 lymphoma L1210 and three L1210 sublines, each resistant to a different anti-leukemic… (More)
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1976
1976
A comparative clinical trial of 5-azacytidine and guanazole in previously treated adults with acute nonlymphocytic leukemia.
Adults with previously treated acute nonlymphocytic leukemia received either 5-azacytidine or guanazole in a randomized study… (More)
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1975
1975
A simple method for long-term drug infusion in mice: evaluation of guanazole as a model (38488).
A simplified technique for iv infusion in unrestricted DBA/2-J inbred mice has been described. The method, which involves direct… (More)
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1975
1975
Guanazole (NSC-1895)--a phase I clinical study.
Two dose schedules of guanazole were used in this phase I clinical study: intermittent prolonged 5-day infusion and intermittent… (More)
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1972
1972
Chromatid breakage: differential effect of inhibitors of DNA synthesis during G 2 phase.
The cell cycle specificity of chromatid breakage induced by inhibitors of DNA synthesis depends on the mechanism of drug action… (More)
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1970
1970
Inhibition of ribonucleotide reductase, DNA synthesis, and L1210 leukemia by guanazole.
Guanazole (3,5-diamino-l,2,4-triazole; NSC 1895) was found to inhibit the incorporation of adenine, hypoxanthine, and uridine… (More)
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