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Guanazole
Known as:
1H-1,2,4-Triazole-3,5-Diamine
, Guanazole [Chemical/Ingredient]
, 3,5-Diamino-1H-1,2,4-Triazole
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A cytostatic triazole derivative antimetabolite. Guanazole scavenges tyrosine free radicals, thereby inhibiting mammalian ribonucleotide reductase…
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National Institutes of Health
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Related topics
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8 relations
Broader (1)
Antineoplastic Agents
In Blood
agonists
analogs & derivatives
antagonists & inhibitors
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
In vitro induction of fetal hemoglobin in human erythroid progenitor cells.
Janie Ho
,
C. V. Pickens
,
M. P. Gamcsik
,
O. Colvin
,
R. Ware
Experimental Hematology
2003
Corpus ID: 25717085
Highly Cited
1982
Highly Cited
1982
Therapeutic response of leukemic mice treated with fluorinated pyrimidines and inhibitors of deoxyuridylate synthesis.
Richard G. Moran
,
Peter V. Danenberg
,
Charles Heidelberger
Biochemical Pharmacology
1982
Corpus ID: 40046827
Highly Cited
1981
Highly Cited
1981
Effect of iron-chelating agents on inhibitors of ribonucleotide reductase.
J. G. Cory
,
L. Lasater
,
A. Sato
Biochemical Pharmacology
1981
Corpus ID: 34653303
1980
1980
Specific inhibition of the subunits of ribonucleotide reductase as a new approach to combination chemotherapy.
Joseph G. Cory
,
Atsushi Sato
,
Linda S. Lasater
Advances in Enzyme Regulation
1980
Corpus ID: 21812334
1980
1980
Studies of mammalian ribonucleotide reductase activity in intact permeabilized cells: a genetic approach.
J. Wright
,
R. Hards
,
J. Dick
Advances in Enzyme Regulation
1980
Corpus ID: 31044634
1976
1976
A comparative clinical trial of 5‐azacytidine and guanazole in previously treated adults with acute nonlymphocytic leukemia
J. Levi
,
P. Wiernik
Cancer
1976
Corpus ID: 34074407
Adults with previously treated acute nonlymphocytic leukemia received either 5‐azacytidine or guanazole in a randomized study…
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Highly Cited
1976
Highly Cited
1976
Randomized clinical comparison of daunorubicin (NSC-82151) alone with a combination of daunorubicin, cytosine arabinoside (NSC-63878), 6-thioguanine (NSC-752), and pyrimethamine (NSC-3061) for the…
P. Wiernik
,
S. Schimpff
,
+4 authors
C. Fortner
Cancer treatment reports
1976
Corpus ID: 9044580
Sixty-six newly diagnosed patients with acute nonlymphocytic leukemia received either daunorubicin alone or a combination of…
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1975
1975
A Simple Method for Long-Term Drug Infusion in Mice: Evaluation of Guanazole as a Model 1
M. A. Paul
,
C. Dave
Proceedings of the Society for Experimental…
1975
Corpus ID: 42910893
Summary A simplified technique for iv infusion in unrestricted DBA/2J inbred mice has been described. The method, which involves…
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1974
1974
Altered ribonucleotide reductase activity in mammalian tissue culture cells resistant to hydroxyurea.
W. H. Lewis
,
J. Wright
Biochemical and Biophysical Research…
1974
Corpus ID: 37617956
1974
1974
Evidence of a common site of action for the antitumor agents, hydroxyurea and guanazole
Jim A. Wright
,
W. H. Lewis
Journal of Cellular Physiology
1974
Corpus ID: 40899225
Hydroxyurea and guanazole were used as selective agents in tissue culture to obtain independent Chinese hamster ovary cell lines…
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