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Guanazole

Known as: 1H-1,2,4-Triazole-3,5-Diamine, Guanazole [Chemical/Ingredient], 3,5-Diamino-1H-1,2,4-Triazole 
A cytostatic triazole derivative antimetabolite. Guanazole scavenges tyrosine free radicals, thereby inhibiting mammalian ribonucleotide reductase… 
National Institutes of Health

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Broader (1)

Antineoplastic Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

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2012
2012
Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors.
Highly Cited
2008
Highly Cited
2008
Synthesis, structure, and physical properties of a new anions-controlled Cd(II)-guanazole (3,5-diamino-1,2,4-triazole) hybrid family.
Nine members of a new anions-controlled Cd(II)-guanazole (3,5-diamino-1,2,4-triazole=Hdatrz) hybrid family, that is, [Cd3(datrz)6… 
Highly Cited
2005
Highly Cited
2005
Formation of refractory ring-expanded triazine intermediates during the photocatalyzed mineralization of the endocrine disruptor amitrole and related triazole derivatives at UV-irradiated TiO2/H2O…
Amitrole (ATz, 3-amino-1H-1,2,4-triazole) is a widely employed herbicide with strong estrogenic activity that can lead to… 
Highly Cited
1982
Highly Cited
1982
Therapeutic response of leukemic mice treated with fluorinated pyrimidines and inhibitors of deoxyuridylate synthesis.
Highly Cited
1981
Highly Cited
1981
Effect of iron-chelating agents on inhibitors of ribonucleotide reductase.
1980
1980
Specific inhibition of the subunits of ribonucleotide reductase as a new approach to combination chemotherapy.
1976
1976
A comparative clinical trial of 5‐azacytidine and guanazole in previously treated adults with acute nonlymphocytic leukemia
Adults with previously treated acute nonlymphocytic leukemia received either 5‐azacytidine or guanazole in a randomized study… 
1974
1974
Altered ribonucleotide reductase activity in mammalian tissue culture cells resistant to hydroxyurea.
1974
1974
Evidence of a common site of action for the antitumor agents, hydroxyurea and guanazole
Hydroxyurea and guanazole were used as selective agents in tissue culture to obtain independent Chinese hamster ovary cell lines… 
Highly Cited
1970
Highly Cited
1970
Inhibition of ribonucleotide reductase, DNA synthesis, and L1210 leukemia by guanazole.
Summary Guanazole (3,5-diamino-1,2,4-triazole; NSC 1895) was found to inhibit the incorporation of adenine, hypoxanthine, and… 
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