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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
It is demonstrated that the cell capable of initiating human AML in non-obese diabetic mice with severe combined immunodeficiency disease (NOD/SCID mice) — termed the SCID leukemia-initiating cell, or SL-IC — possesses the differentiate and proliferative capacities and the potential for self-renewal expected of a leukemic stem cell. Expand
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
The identification of colon cancer stem cells that are distinct from the bulk tumour cells provides strong support for the hierarchical organization of human colon cancer, and their existence suggests that for therapeutic strategies to be effective, they must target the cancer stem Cells. Expand
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
This in vivo model replicates many aspects of human AML and defines a new leukaemia-initiating cell which is less mature than colony-forming cells. Expand
Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.
A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell model for tumor development and progression. The meeting participants were charged with evaluating data suggestingExpand
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
The mutational spectrum is similar to myeloid tumours, and moreover, the global transcriptional profile of ETP ALL was similar to that of normal andMyeloid leukaemia haematopoietic stem cells, suggesting that addition of myeloids-directed therapies might improve the poor outcome of E TP ALL. Expand
Targeting of CD44 eradicates human acute myeloid leukemic stem cells
It is demonstrated that absence of leukemia in serially transplanted mice demonstrated that AML LSCs are directly targeted, and mechanisms underlying this eradication included interference with transport to stem cell–supportive microenvironmental niches and alteration of AML-LSC fate. Expand
Stem cell gene expression programs influence clinical outcome in human leukemia
It is shown that acute myeloid leukemia (AML) follows a CSC model on the basis of sorting multiple populations from each of 16 primary human AML samples and identifying which contain leukemia stem cells (LSCs) using a sensitive xenograft assay, establishing that LSCs are clinically relevant and not artifacts of xenotransplantation. Expand
Evolution of the cancer stem cell model.
It is proposed that the genetic and CSC models of cancer can be harmonized by considering the role of genetic diversity and nongenetic influences in contributing to tumor heterogeneity. Expand
Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment
Proteins are identified that underlie the early commitment steps of human hematopoietic stem cell differentiation and will enable the investigation of the molecular determinants of HSCs, with a goal of developing stem cell–based therapeutics. Expand
Corrigendum: Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is based on a two-step process, not a single step, called a “shots fired” process. Expand