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Glycosylation End Products, Advanced

Known as: Advanced Glycation End Products, Advanced Glycation End-Product, Advanced Glycation Endproducts 
Products derived from the nonenzymatic reaction of GLUCOSE and PROTEINS in vivo that exhibit a yellow-brown pigmentation and an ability to… 
National Institutes of Health

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Diabetes MellitusIn BloodProcess of secretionagonists

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glucosepane

Papers overview

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Review
2015
Review
2015
Cardiovascular Consequences of Obesity and Type 2 Diabetes Damaging effects of hyperglycemia on cardiovascular function : spotlight on glucose metabolic pathways
Mapanga RF, Essop MF. Damaging effects of hyperglycemia on cardiovascular function: spotlight on glucose metabolic pathways. Am J… 
Highly Cited
2004
Highly Cited
2004
Association between acute-phase reactants and advanced glycation end products in type 2 diabetes.
OBJECTIVE Type 2 diabetes is associated with chronic low-grade inflammation, but the underlying mechanism(s) is not well… 
Highly Cited
1999
Highly Cited
1999
Characterization of the advanced glycation end-product receptor complex in human vascular endothelial cells.
Advanced glycation end products (AGEs) have been implicated as causal factors in the vascular complications of diabetes and it is… 
Highly Cited
1999
Highly Cited
1999
Diabetic retinopathy risk correlates with intracellular concentrations of the glycoxidation product Ne-(carboxymethyl) lysine independently of glycohaemoglobin concentrations
Aims/hypothesis. We investigated whether either the amount of diabetes-induced intracellular oxidative stress or the… 
Highly Cited
1998
Highly Cited
1998
The advanced glycation end product Nepsilon-(carboxymethyl)lysine is increased in serum from children and adolescents with type 1 diabetes.
OBJECTIVE To investigate whether children and adolescents with type 1 diabetes have increased serum levels of the glycoxidation… 
Highly Cited
1997
Highly Cited
1997
Relative contributions of advanced glycation and nitric oxide synthase inhibition to aminoguanidine-mediated renoprotection in diabetic rats
Summary Advanced glycation end products (AGEs) have previously been shown to be increased in the diabetic kidney. Aminoguanidine… 
Highly Cited
1997
Highly Cited
1997
Methylglyoxal-modified arginine residues--a signal for receptor-mediated endocytosis and degradation of proteins by monocytic THP-1 cells.
Highly Cited
1995
Highly Cited
1995
Receptor-mediated toxicity to pericytes of advanced glycosylation end products: a possible mechanism of pericyte loss in diabetic microangiopathy.
The influence of advanced glycosylation end products (AGE) on bovine retinal pericytes was investigated. When pericytes were… 
Review
1988
Review
1988
Role of advanced glycosylation products in complications of diabetes.
Glucose and other reducing sugars can react with proteins and nucleic acids, without the aid of enzymes, to form stable covalent… 
Highly Cited
1988
Highly Cited
1988
Specific Macrophage Receptor Activity for Advanced Glycosylation End Products Inversely Correlates With Insulin Levels In Vivo
A high-affinity macrophage receptor has been shown to mediate the removal of proteins modified by advanced nonenzymatic… 
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