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Glucocorticoid Receptor Deficiency
Known as:
Cortisol Resistance from Glucocorticoid Receptor Defect
, GCCR DEFICIENCY
, GCCR
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An autosomal dominant condition due to mutation(s) in the NR3C1 gene, encoding the glucocorticoid receptor, resulting in decreased receptor affinity…
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National Institutes of Health
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Related topics
Related topics
7 relations
Autosomal dominant inheritance
Fatigue
Hypertensive disease
Hypoglycemia
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Broader (2)
Glucocorticoid Receptor
Inborn Errors of Metabolism
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice.
John A. Marwick
,
G. Caramori
,
+7 authors
A. Papi
American Journal of Respiratory and Critical Care…
2009
Corpus ID: 41183405
RATIONALE There is an increasing prevalence of reduced responsiveness to glucocorticoid therapy in severe asthma and chronic…
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Highly Cited
2008
Highly Cited
2008
Leukaemia in young children living in the vicinity of German nuclear power plants
P. Kaatsch
,
C. Spix
,
R. Schulze‐Rath
,
S. Schmiedel
,
M. Blettner
International Journal of Cancer
2008
Corpus ID: 9416286
A case control study was conducted where cases were children younger than 5 years (diseased between 1980 and 2003) registered at…
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Review
2008
Review
2008
Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder.
E. Charmandari
,
T. Kino
,
T. Ichijo
,
G. Chrousos
Journal of Clinical Endocrinology and Metabolism
2008
Corpus ID: 1445997
CONTEXT Primary generalized glucocorticoid resistance is a rare genetic condition characterized by generalized, partial, target…
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Highly Cited
2004
Highly Cited
2004
Effects of repeated social stress on leukocyte distribution in bone marrow, peripheral blood and spleen
H. Engler
,
M. Bailey
,
A. Engler
,
J. Sheridan
Journal of Neuroimmunology
2004
Corpus ID: 8137081
Highly Cited
2002
Highly Cited
2002
Prolonged methylprednisolone treatment suppresses systemic inflammation in patients with unresolving acute respiratory distress syndrome: evidence for inadequate endogenous glucocorticoid secretion…
G. Meduri
,
E. Tolley
,
G. Chrousos
,
F. Stentz
American Journal of Respiratory and Critical Care…
2002
Corpus ID: 888397
Nuclear factor-kappaB (NF-kappaB) and glucocorticoid receptor-alpha (GR-alpha) have diametrically opposed functions in regulating…
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Highly Cited
2001
Highly Cited
2001
Population‐based epidemiologic data on brain tumors in German children
P. Kaatsch
,
C. Rickert
,
J. Kühl
,
J. Schüz
,
J. Michaelis
Cancer
2001
Corpus ID: 42997892
Brain tumors are the most common disease group of solid tumors in childhood, and children with brain tumors have a relatively…
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Highly Cited
2000
Highly Cited
2000
Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor β-isoform
Ana R. Sousa
,
Ana R. Sousa
,
+7 authors
Tak H. Lee
2000
Corpus ID: 28491373
Abstract Background: Glucocorticoid-resistant bronchial asthma is characterized by failure of corticosteroids to suppress key…
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Highly Cited
1999
Highly Cited
1999
Effects of Cytokines on Glucocorticoid Receptor Expression And Function
A. Miller
,
C. Pariante
,
B. D. Pearce
1999
Corpus ID: 37294136
A large body of data has been amassed which convincingly demonstrates that the immune system and the nervous system extensively…
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Highly Cited
1999
Highly Cited
1999
Glucocorticoid resistance in the squirrel monkey is associated with overexpression of the immunophilin FKBP51.
P. D. Reynolds
,
Y. Ruan
,
D. F. Smith
,
J. Scammell
Journal of Clinical Endocrinology and Metabolism
1999
Corpus ID: 22523971
Squirrel monkeys are neotropical primates that have high circulating cortisol to compensate for expression of glucocorticoid…
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Highly Cited
1991
Highly Cited
1991
Glucocorticoid resistance in chronic asthma. Glucocorticoid pharmacokinetics, glucocorticoid receptor characteristics, and inhibition of peripheral blood T cell proliferation by glucocorticoids in…
C. Corrigan
,
P. Brown
,
+4 authors
A. Kay
American Review of Respiratory Disease
1991
Corpus ID: 24856316
A total of 37 chronic, severe, nonsmoking asthmatic patients with documented reversible airways obstruction were classified as…
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