Glucocorticoid Receptor Deficiency

Known as: Cortisol Resistance from Glucocorticoid Receptor Defect, GCCR DEFICIENCY, GCCR 
An autosomal dominant condition due to mutation(s) in the NR3C1 gene, encoding the glucocorticoid receptor, resulting in decreased receptor affinity… (More)
National Institutes of Health

Papers overview

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Review
2011
Review
2011
Major depression (MD) is a common psychiatric disorder with a complex and multifactor aetiology. Potential mechanisms associated… (More)
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Highly Cited
2010
Highly Cited
2010
In vivo resistance to first-line chemotherapy, including to glucocorticoids, is a strong predictor of poor outcome in children… (More)
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Review
2009
Review
2009
Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several common inflammatory diseases-including… (More)
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Review
2008
Review
2008
Childhood trauma is a potent risk factor for developing depression in adulthood, particularly in response to additional stress… (More)
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Review
2007
Review
2007
Glucocorticoids play an essential role in the response to environmental stressors, serving initially to mobilize bodily responses… (More)
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Highly Cited
2006
Highly Cited
2006
Drug resistance remains a major obstacle to successful cancer treatment. A database of drug-associated gene expression profiles… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND The causes and clinical course of acute rejection vary, and it is not possible to predict graft outcome reliably on… (More)
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Highly Cited
2001
Highly Cited
2001
Inflammatory responses in many cell types are coordinately regulated by the opposing actions of NF-kappaB and the glucocorticoid… (More)
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Highly Cited
1999
Highly Cited
1999
Alternative splicing of the human glucocorticoid receptor gene generates a nonhormone binding splice variant (hGRbeta) that… (More)
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Highly Cited
1986
Highly Cited
1986
We isolated and sequenced 6.3 kb of cDNA encoding that rat glucocorticoid receptor, a protein that binds and activates a class of… (More)
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